A series of novel analogs of water soluble pterostilbene amino acid bearing carbonates were synthesized, which show activities in treating a non-alcoholic fatty liver disease and a nonalcoholic steatohepatitis (NASH).

A series of novel analogs of water soluble pterostilbene amino acid bearing carbonates were synthesized, which show activities in treating a non-alcoholic fatty liver disease and a nonalcoholic steatohepatitis (NASH).

A compound having Formula (I) or Formula (II):

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or a mixture thereof,

in which R is —H; —CH.sub.3; —CH—(CH.sub.3).sub.2; —CH.sub.2—CH—(CH.sub.3).sub.2; —CH—(CH.sub.3)—CH.sub.2—CH.sub.3; —CH.sub.2—(C.sub.6H.sub.5); —CH.sub.2—(3-indole); —CH.sub.2—CH.sub.2—S—CH.sub.3; —CH.sub.2—OH; —CH—(CH.sub.3)—OH; —CH.sub.2—SH; —CH.sub.2-(p-C.sub.6H.sub.40H); —CH.sub.2—CH.sub.2—CH.sub.2—CH.sub.2—NH.sub.2; —CH.sub.2—CO—NH.sub.2; —CH.sub.2—CH.sub.2—CO—NH.sub.2; —CH.sub.2—CH.sub.2—COOH; —CH.sub.2—COOH; or —CH.sub.2—CH.sub.2—NH—C═NH.sub.2(NH.sub.2);

and X is a suitable non-interfering anion, a process for making the compound having Formula (I) or Formula (II), and a process for reacting the compound having Formula (I) or Formula (II) or a mixture thereof with a (poly)saccharide to form a cationized (poly)saccharide.

The present disclosures are directed to processes for synthesizing (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide (“nirogacestat”).

The present disclosures are directed to processes for synthesizing (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide (“nirogacestat”).

The invention provides novel iron(III) complexes with formulae (1) and (2). Furthermore, corresponding ligands with formulae (L1) and (L2) for the production of iron(III) complexes are disclosed.

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The present invention generally relates to a chemical process under flow conditions for manufacturing compounds which absorb ultraviolet (UV) radiation and protect biological materials as well as non-biological materials from damaging exposure to UV radiation. The present invention further includes formulations and compositions comprising such compounds for use in absorbing UV radiation, as well as methods for protecting biological materials as well as non-biological materials from damaging exposure to UV radiation.

The present invention generally relates to a chemical process under flow conditions for manufacturing compounds which absorb ultraviolet (UV) radiation and protect biological materials as well as non-biological materials from damaging exposure to UV radiation. The present invention further includes formulations and compositions comprising such compounds for use in absorbing UV radiation, as well as methods for protecting biological materials as well as non-biological materials from damaging exposure to UV radiation.

Disclosed herein are compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), methods of synthesizing compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), and methods of using compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It) as an analgesic.

In some embodiments, the present disclosure provides amino acid compounds that are useful for producing products such as peptides. In some embodiments, the present disclosure provides peptides comprising residues of provided amino acids.