Compounds are provided that function as thyromimetics, which compounds have utility for treating diseases such as neurodegenerative disorders. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation. Such compounds have the structure of Formula (I) as shown herein, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof.

Compounds are provided that function as thyromimetics, which compounds have utility for treating diseases such as neurodegenerative disorders. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation. Such compounds have the structure of Formula (I) as shown herein, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof.

Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein Q, Y, R.sup.1a, R.sup.1b, Z, W, R.sup.2, R.sup.3, R.sup.4, m, R.sup.5a and R.sup.5b are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

##STR00001##

Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein Q, Y, R.sup.1a, R.sup.1b, Z, W, R.sup.2, R.sup.3, R.sup.4, m, R.sup.5a and R.sup.5b are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

##STR00001##

The present invention provides a composition having an excellent control efficacy against plant diseases, and a method for controlling plant diseases using the same composition, and the composition comprises a compound represented by formula (I) [wherein each symbol represents the definition described in the specification], and one or more compounds selected from a mitochondrial electron transport chain complex III inhibitor, a mitochondrial electron transport chain complex II inhibitor, and a sterol biosynthesis inhibitor.

##STR00001##

The fluorene derivative of the present disclosure is represented by the following formula (1):

##STR00001##

Wherein R.sup.1 represents a substituent, k denotes an integer of 0 to 8, R.sup.2a, R.sup.2b, R.sup.2c, and R.sup.2d each represent a hydrogen atom or a substituent, R.sup.3a and R.sup.3b each represent a hydrogen atom or a substituent, and X.sup.1a and X.sup.1b each represent a group defined in the following formula (X1):

##STR00002##

wherein R.sup.4 and R.sup.5 each represent a hydrogen atom or an aliphatic hydrocarbon group, provided that the case where both R.sup.4 and R.sup.5 are a hydrogen atom is excluded; or R.sup.4 and R.sup.5 bond together to form a heterocyclic ring containing the nitrogen atom adjacent to R.sup.4 and R.sup.5. The present disclosure provides a novel fluorene derivative useful as an additive for improving the properties of a resin, a method for producing the same and a use thereof.

The fluorene derivative of the present disclosure is represented by the following formula (1):

##STR00001##

Wherein R.sup.1 represents a substituent, k denotes an integer of 0 to 8, R.sup.2a, R.sup.2b, R.sup.2c, and R.sup.2d each represent a hydrogen atom or a substituent, R.sup.3a and R.sup.3b each represent a hydrogen atom or a substituent, and X.sup.1a and X.sup.1b each represent a group defined in the following formula (X1):

##STR00002##

wherein R.sup.4 and R.sup.5 each represent a hydrogen atom or an aliphatic hydrocarbon group, provided that the case where both R.sup.4 and R.sup.5 are a hydrogen atom is excluded; or R.sup.4 and R.sup.5 bond together to form a heterocyclic ring containing the nitrogen atom adjacent to R.sup.4 and R.sup.5. The present disclosure provides a novel fluorene derivative useful as an additive for improving the properties of a resin, a method for producing the same and a use thereof.

The use of compounds according to formula (I)

##STR00001##

and with X, Y═—NH— or —O—, wherein at least X or Y is —NH—,
in the form of any one of its stereoisomers or a mixture thereof, wherein
is indicating a carbon-carbon single or double bond, and wherein one carbon-carbon double bond is present either at C2 or C3,
the wavy bond is indicating an unspecified configuration of the adjacent double bond, as umami tastant.

The use of compounds according to formula (I)

##STR00001##

and with X, Y═—NH— or —O—, wherein at least X or Y is —NH—,
in the form of any one of its stereoisomers or a mixture thereof, wherein
is indicating a carbon-carbon single or double bond, and wherein one carbon-carbon double bond is present either at C2 or C3,
the wavy bond is indicating an unspecified configuration of the adjacent double bond, as umami tastant.

A group of novel 9H-fluorene derivatives suitable for the preparation of active substances for the treatment of Alzheimer's disease, in particular as multifunctional inhibitors of the BuChE and BACE1 enzymes and beta-amyloid aggregation.