The present invention relates to hyper-branched compounds, a method of synthesizing the hyper-branched compounds and applications of the hyper-branched compounds. The hyper-branched compounds of the present invention include hyper-branched fluorinated compounds, hyper-branched fluorinated graphene and hyper-branched amine functionalized graphene oxide.

The present invention relates to hyper-branched compounds, a method of synthesizing the hyper-branched compounds and applications of the hyper-branched compounds. The hyper-branched compounds of the present invention include hyper-branched fluorinated compounds, hyper-branched fluorinated graphene and hyper-branched amine functionalized graphene oxide.

The present invention provides a pharmaceutical composition for treating or preventing a cognitive disease or disorder, comprising a compound represented by Formula (I), an enantiomer thereof a diastereomer thereof, or a pharmaceutically acceptable salt thereof.

The present invention provides a pharmaceutical composition for treating or preventing a cognitive disease or disorder, comprising a compound represented by Formula (I), an enantiomer thereof a diastereomer thereof, or a pharmaceutically acceptable salt thereof.

Disclosed are small molecule PLK inhibitors that can target the polo box domain (PBD). Inhibitors can have an atomic mass of about 1000 Da or less and a general structure of ##STR00001##
For instance, the inhibitors can include an alkyl benzamido benzoic acid core structure.

Disclosed are small molecule PLK inhibitors that can target the polo box domain (PBD). Inhibitors can have an atomic mass of about 1000 Da or less and a general structure of ##STR00001##
For instance, the inhibitors can include an alkyl benzamido benzoic acid core structure.

A process for preparing 1,1,3-trimethylindan-4-amine of formula (I), or a salt thereof, enriched in one of its two enantiomers, in particular the (R) enantiomer,

##STR00001##

including chirally separating an optionally substituted 2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline of formula (III)

##STR00002##

A process may prepare one or more optically active amides of formula (II)

##STR00003##

starting from compounds of formula (I).

A process for preparing 1,1,3-trimethylindan-4-amine of formula (I), or a salt thereof, enriched in one of its two enantiomers, in particular the (R) enantiomer,

##STR00001##

including chirally separating an optionally substituted 2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline of formula (III)

##STR00002##

A process may prepare one or more optically active amides of formula (II)

##STR00003##

starting from compounds of formula (I).

Certain embodiments describe antiviral compounds and related methods of using such compounds.

The present application provides antibiotic compounds, as well as pharmaceutical compositions comprising these compounds, and methods of treating bacterial infections using these compounds