Patent classifications
C07C311/43
Methods and compositions for targeting Tregs using CCR8 inhibitors
The present invention provides compounds of Formula (I) which can be used as CCR8 inhibitors, which can be used as treatment or prevention of cancer using CCR8 inhibitors targeted tumor specific T regulatory cells.
##STR00001##
3,4-DISUBSTITUTED 3-CYCLOBUTENE-1,2-DIONES AND USE THEREOF
Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula:
##STR00001##
The compounds are useful for treating inflammatory and autoimmune diseases.
3,4-DISUBSTITUTED 3-CYCLOBUTENE-1,2-DIONES AND USE THEREOF
Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula:
##STR00001##
The compounds are useful for treating inflammatory and autoimmune diseases.
Methods and Compositions for Targeting Tregs using CCR8 Inhibitors
The present invention provides compounds of Formula (I) which can be used as CCR8 inhibitors, which can be used as treatment or prevention of cancer using CCR8 inhibitors targeted tumor specific T regulatory cells.
##STR00001##
3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof
Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula: ##STR00001## The compounds are useful for treating inflammatory and autoimmune diseases.
3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof
Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula: ##STR00001## The compounds are useful for treating inflammatory and autoimmune diseases.
MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION
The present invention relates to a compound of Formula la, lb and Ic, (Formula Ia) a pharmaceutical composition comprising the same and their use in the treatment or prevention of pathological conditions associated to depolarizing GABAergic transmission including, for example, Down syndrome and autism.
##STR00001##
MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION
The present invention relates to a compound of Formula la, lb and Ic, (Formula Ia) a pharmaceutical composition comprising the same and their use in the treatment or prevention of pathological conditions associated to depolarizing GABAergic transmission including, for example, Down syndrome and autism.
##STR00001##
WDR5-MYC INHIBITORS
Substituted N-phenyl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.
WDR5-MYC INHIBITORS
Substituted N-phenyl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.