Patent classifications
C07C311/46
Methods and compositions for targeting Tregs using CCR8 inhibitors
The present invention provides compounds of Formula (I) which can be used as CCR8 inhibitors, which can be used as treatment or prevention of cancer using CCR8 inhibitors targeted tumor specific T regulatory cells.
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Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
- Joseph D. Eckelbarger ,
- Daniel I. Knueppel ,
- Ronald J. Heemstra ,
- Ronald Ross, Jr. ,
- Kyle A. DeKorver ,
- Kaitlyn Gray ,
- Peter Vednor ,
- Timothy P. Martin ,
- Ricky Hunter ,
- David A. Demeter ,
- Tony K. Trullinger ,
- Erich W. Baum ,
- Zoltan L. Benko ,
- Nakyen Choy ,
- Gary D. Crouse ,
- John F. Daeuble, SR. ,
- Fangzheng Li ,
- Jeffrey Nissen ,
- Michelle Riener ,
- Thomas C. Sparks ,
- Frank J. Wessels ,
- Maurice C. Yap
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
##STR00001##
Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
- Joseph D. Eckelbarger ,
- Daniel I. Knueppel ,
- Ronald J. Heemstra ,
- Ronald Ross, Jr. ,
- Kyle A. DeKorver ,
- Kaitlyn Gray ,
- Peter Vednor ,
- Timothy P. Martin ,
- Ricky Hunter ,
- David A. Demeter ,
- Tony K. Trullinger ,
- Erich W. Baum ,
- Zoltan L. Benko ,
- Nakyen Choy ,
- Gary D. Crouse ,
- John F. Daeuble, SR. ,
- Fangzheng Li ,
- Jeffrey Nissen ,
- Michelle Riener ,
- Thomas C. Sparks ,
- Frank J. Wessels ,
- Maurice C. Yap
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
##STR00001##
Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
- Timothy P. Martin ,
- Joseph D. Eckelbarger ,
- Ronald Ross, Jr. ,
- Kyle A. DeKorver ,
- Ronald J. Heemstra ,
- Daniel I. Knueppel ,
- Peter Vednor ,
- Ricky Hunter ,
- David A. Demeter ,
- Tony K. Trullinger ,
- Erich W. Baum ,
- Zoltan L. Benko ,
- Nakyen Choy ,
- Gary D. Crouse ,
- John F. Daeuble, SR. ,
- Fangzheng Li ,
- Jeffrey Nissen ,
- Michelle Riener ,
- Thomas C. Sparks ,
- Frank J. Wessels ,
- Maurice C. Yap
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
##STR00001##
Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
- Timothy P. Martin ,
- Joseph D. Eckelbarger ,
- Ronald Ross, Jr. ,
- Kyle A. DeKorver ,
- Ronald J. Heemstra ,
- Daniel I. Knueppel ,
- Peter Vednor ,
- Ricky Hunter ,
- David A. Demeter ,
- Tony K. Trullinger ,
- Erich W. Baum ,
- Zoltan L. Benko ,
- Nakyen Choy ,
- Gary D. Crouse ,
- John F. Daeuble, SR. ,
- Fangzheng Li ,
- Jeffrey Nissen ,
- Michelle Riener ,
- Thomas C. Sparks ,
- Frank J. Wessels ,
- Maurice C. Yap
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
##STR00001##
Methods and compositions useful in treating cancer and reducing WNT mediated effects in a cell
Provided herein are novel compounds, pharmaceutical compositions for use, inter alia, in methods of reducing Wnt-mediated effects and treating cancer.
Methods and compositions useful in treating cancer and reducing WNT mediated effects in a cell
Provided herein are novel compounds, pharmaceutical compositions for use, inter alia, in methods of reducing Wnt-mediated effects and treating cancer.
Small molecule inhibitors selective for polo-like kinase proteins
Disclosed are small molecule PLK inhibitors that can target the polo box domain (PBD). Inhibitors can have an atomic mass of about 1000 Da or less and a general structure of ##STR00001##
For instance, the inhibitors can include an alkyl benzamido benzoic acid core structure.
Small molecule inhibitors selective for polo-like kinase proteins
Disclosed are small molecule PLK inhibitors that can target the polo box domain (PBD). Inhibitors can have an atomic mass of about 1000 Da or less and a general structure of ##STR00001##
For instance, the inhibitors can include an alkyl benzamido benzoic acid core structure.
Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
- Ronald J. Heemstra ,
- Ronald Ross, Jr. ,
- Kyle A. DeKorver ,
- Kaitlyn Gray ,
- Daniel I. Knueppel ,
- Peter Vednor ,
- Timothy P. Martin ,
- Joseph D. Eckelbarger ,
- John F. Daeuble, SR. ,
- Ricky Hunter ,
- David A. Demeter ,
- Tony K. Trullinger ,
- Erich W. Baum ,
- Zoltan L. Benko ,
- Nakyen Choy ,
- Gary D. Crouse ,
- Fangzheng Li ,
- Jeffrey Nissen ,
- Monica B. Olson ,
- Michelle Riener ,
- Thomas C. Sparks ,
- Frank J. Wessels ,
- Maurice C. Yap
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”). ##STR00001##