The present invention discloses a hypocrellin derivative substituted both in a pen-position and in a 2-position by an amino, and a preparation method and use thereof. A general structural formula of the derivative is as represented by formulas I-a to I-d: ##STR00001## The hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino prepared in the present invention has a maximum absorption wavelength of 600-650 nm and a molar extinction coefficient reaching about 20000-40000 M.sup.−1cm.sup.−1. Compared with unmodified hypocrellin or hypocrellin having only a 2-position modified, an absorption spectrum of the derivative is significantly red-shifted and the molar extinction coefficient is greatly improved, and the derivative can efficiently produce reactive oxygen species such as singlet oxygen in a photosensitive condition. In the same condition, the hypocrellin derivative substituted both in a pen-position and in a 2-position by an amino involved in the present invention, when used as a photosensitizer, has a stronger ability to photo-dynamically inactivate tumor cells than the first and second generation commercial photosensitizers.

The present invention discloses a hypocrellin derivative substituted both in a pen-position and in a 2-position by an amino, and a preparation method and use thereof. A general structural formula of the derivative is as represented by formulas I-a to I-d: ##STR00001## The hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino prepared in the present invention has a maximum absorption wavelength of 600-650 nm and a molar extinction coefficient reaching about 20000-40000 M.sup.−1cm.sup.−1. Compared with unmodified hypocrellin or hypocrellin having only a 2-position modified, an absorption spectrum of the derivative is significantly red-shifted and the molar extinction coefficient is greatly improved, and the derivative can efficiently produce reactive oxygen species such as singlet oxygen in a photosensitive condition. In the same condition, the hypocrellin derivative substituted both in a pen-position and in a 2-position by an amino involved in the present invention, when used as a photosensitizer, has a stronger ability to photo-dynamically inactivate tumor cells than the first and second generation commercial photosensitizers.

The present invention discloses a hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino, and a preparation method and use thereof. A general structural formula of the derivative is as represented by formulas I-a to I-d:

##STR00001##

The hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino prepared in the present invention has a maximum absorption wavelength of 600-650 nm and a molar extinction coefficient reaching about 20000-40000 M.sup.−1cm.sup.−1. Compared with unmodified hypocrellin or hypocrellin having only a 2-position modified, an absorption spectrum of the derivative is significantly red-shifted and the molar extinction coefficient is greatly improved, and the derivative can efficiently produce reactive oxygen species such as singlet oxygen in a photosensitive condition. In the same condition, the hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino involved in the present invention, when used as a photosensitizer, has a stronger ability to photo-dynamically inactivate tumor cells than the first and second generation commercial photosensitizers.

The present invention discloses a hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino, and a preparation method and use thereof. A general structural formula of the derivative is as represented by formulas I-a to I-d:

##STR00001##

The hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino prepared in the present invention has a maximum absorption wavelength of 600-650 nm and a molar extinction coefficient reaching about 20000-40000 M.sup.−1cm.sup.−1. Compared with unmodified hypocrellin or hypocrellin having only a 2-position modified, an absorption spectrum of the derivative is significantly red-shifted and the molar extinction coefficient is greatly improved, and the derivative can efficiently produce reactive oxygen species such as singlet oxygen in a photosensitive condition. In the same condition, the hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino involved in the present invention, when used as a photosensitizer, has a stronger ability to photo-dynamically inactivate tumor cells than the first and second generation commercial photosensitizers.

The invention relates to bimesogenic compounds of formula I ##STR00001##
wherein R.sup.11, R.sup.12, MG.sup.11, MG.sup.12, X.sup.11, X.sup.12 and Sp.sup.1 have the meaning given in claim 1, to the use of bimesogenic compounds of formula l in liquid crystal media and particular to flexoelectric liquid crystal devices comprising a liquid crystal medium according to the present invention.

The invention relates to bimesogenic compounds of formula I ##STR00001##
wherein R.sup.11, R.sup.12, MG.sup.11, MG.sup.12, X.sup.11, X.sup.12 and Sp.sup.1 have the meaning given in claim 1, to the use of bimesogenic compounds of formula l in liquid crystal media and particular to flexoelectric liquid crystal devices comprising a liquid crystal medium according to the present invention.

The present invention is an anthraquinone compound represented by formula (1) (in the formula. R.sub.1 represents a hydrogen atom, a C1-C12 linear or branched alkyl group, or a C1-C12 linear or branched alkoxy group, and R.sub.2 represents a substituent represented by: formula (a) (in formula (a), R.sub.3 represents a hydrogen atom, a C1-C8 linear or branched alkyl group, a C1-C8 linear or branched alkoxy group, or a substituent represented by CH.sub.2OR.sub.4, where R.sub.4 represents a C1-C8 linear or branched alkyl group); or formula (b) (in formula (b). R.sub.5 represents a hydrogen atom, a C1-C8 linear or branched alkyl group, or a substituent represented by CH.sub.2OR.sub.6, where R.sub.6 represents a C1-C8 linear or branched alkyl group)).

##STR00001##

The present invention is an anthraquinone compound represented by formula (1) (in the formula. R.sub.1 represents a hydrogen atom, a C1-C12 linear or branched alkyl group, or a C1-C12 linear or branched alkoxy group, and R.sub.2 represents a substituent represented by: formula (a) (in formula (a), R.sub.3 represents a hydrogen atom, a C1-C8 linear or branched alkyl group, a C1-C8 linear or branched alkoxy group, or a substituent represented by CH.sub.2OR.sub.4, where R.sub.4 represents a C1-C8 linear or branched alkyl group); or formula (b) (in formula (b). R.sub.5 represents a hydrogen atom, a C1-C8 linear or branched alkyl group, or a substituent represented by CH.sub.2OR.sub.6, where R.sub.6 represents a C1-C8 linear or branched alkyl group)).

##STR00001##

An organic electroluminescent element that uses a compound expressed by the following general formula emits dark blue light and exhibits little change in chromaticity during brightness modulation. (n1 is an integer from 0 to 8; the R.sup.1 [groups] are each independently a substituent substituted for a hydrogen atom of the pyrene skeleton; X is CR.sup.aR.sup.b (R.sup.a and R.sup.b are each independently a hydrogen atom or a substituent), O, S, or SiR.sup.dR.sup.e (R.sup.d and R.sup.e are each independently a hydrogen atom or a substituent); and A.sup.1 to A.sup.4 represent each independently either N or CR.sup.f (R.sup.f represents a hydrogen atom or a substituent, and two adjacent R.sup.f [groups] may jointly form a saturated or unsaturated ring, but no more than two rings may be formed jointly by two or more of the R.sup.f [groups]).)

An organic electroluminescent element that uses a compound expressed by the following general formula emits dark blue light and exhibits little change in chromaticity during brightness modulation. (n1 is an integer from 0 to 8; the R.sup.1 [groups] are each independently a substituent substituted for a hydrogen atom of the pyrene skeleton; X is CR.sup.aR.sup.b (R.sup.a and R.sup.b are each independently a hydrogen atom or a substituent), O, S, or SiR.sup.dR.sup.e (R.sup.d and R.sup.e are each independently a hydrogen atom or a substituent); and A.sup.1 to A.sup.4 represent each independently either N or CR.sup.f (R.sup.f represents a hydrogen atom or a substituent, and two adjacent R.sup.f [groups] may jointly form a saturated or unsaturated ring, but no more than two rings may be formed jointly by two or more of the R.sup.f [groups]).)