The present disclosure relates to isolating one or more cannabinoids from an input mixture. There is disclosed an apparatus that comprises a volatizing unit, a fractional distillation unit, and a condensing unit. The volatizing unit receives and volatilizes the input mixture to provide a cannabinoid-containing vapor stream and a residue. The fractional distillation unit comprises a plenum for receiving the cannabinoid-containing vapor stream and separates a first cannabinoid from at least a second cannabinoid. The condensing unit is configured to receive a portion of the cannabinoid-containing vapor stream comprising the first cannabinoid from the plenum and to form a condensed first cannabinoid output stream and a recirculate stream. There are also disclosed methods for isolating one or more cannabinoids employing a recirculate stream.

The present disclosure relates to isolating one or more cannabinoids from an input mixture. There is disclosed an apparatus that comprises a volatizing unit, a fractional distillation unit, and a condensing unit. The volatizing unit receives and volatilizes the input mixture to provide a cannabinoid-containing vapor stream and a residue. The fractional distillation unit comprises a plenum for receiving the cannabinoid-containing vapor stream and separates a first cannabinoid from at least a second cannabinoid. The condensing unit is configured to receive a portion of the cannabinoid-containing vapor stream comprising the first cannabinoid from the plenum and to form a condensed first cannabinoid output stream and a recirculate stream. There are also disclosed methods for isolating one or more cannabinoids employing a recirculate stream.

The present disclosure relates to isolating one or more cannabinoids from an input mixture. There is disclosed an apparatus that comprises a volatizing unit, a fractional distillation unit, and a condensing unit. The volatizing unit receives and volatilizes the input mixture to provide a cannabinoid-containing vapor stream and a residue. The fractional distillation unit comprises a plenum for receiving the cannabinoid-containing vapor stream and separates a first cannabinoid from at least a second cannabinoid. The condensing unit is configured to receive a portion of the cannabinoid-containing vapor stream comprising the first cannabinoid from the plenum and to form a condensed first cannabinoid output stream and a recirculate stream. There are also disclosed methods for isolating one or more cannabinoids employing a recirculate stream.

A method of making CBD concentrate or CBD Isolate comprises (a) milling a raw material; (b) contacting the milled raw material with an extraction solvent and separating a solid waste material to form a filtered extract; (c) concentrating the filtered extract; (d) washing the concentrated extract to form an organic phase and an aqueous phase; (e) separating the aqueous phase from the organic phase to form a washed extract; (f) removing an organic solvent from the washed extract to form a concentrated washed extract; (g) decarboxylating the concentrated washed extract; (h) vacuum distilling the decarboxylated extract to form a distillate; (i) dewaxing the distillate to form a post-dewax filtrate; (j) applying a vacuum to the post-dewax filtrate to form a post-dewax concentrate; (k) degassing the post-dewax concentrate; and (l) vacuum distilling the degassed concentrate to form a CBD concentrate.

A method of making CBD concentrate or CBD Isolate comprises (a) milling a raw material; (b) contacting the milled raw material with an extraction solvent and separating a solid waste material to form a filtered extract; (c) concentrating the filtered extract; (d) washing the concentrated extract to form an organic phase and an aqueous phase; (e) separating the aqueous phase from the organic phase to form a washed extract; (f) removing an organic solvent from the washed extract to form a concentrated washed extract; (g) decarboxylating the concentrated washed extract; (h) vacuum distilling the decarboxylated extract to form a distillate; (i) dewaxing the distillate to form a post-dewax filtrate; (j) applying a vacuum to the post-dewax filtrate to form a post-dewax concentrate; (k) degassing the post-dewax concentrate; and (l) vacuum distilling the degassed concentrate to form a CBD concentrate.

Various aspects of this patent document relate to compositions and methods to purify cannabinoids by crystallization in a water-miscible liquid.

Various aspects of this patent document relate to compositions and methods to purify cannabinoids by crystallization in a water-miscible liquid.

Systems and methods for extracting a compound of interest from plant material, such as a cannabidiol (CBD) from cannabis, are provided. Particularly, the disclosed systems and methods utilize a crude oil to separate water and impurities including fats, sugars, resin glues, chlorophyll, and proteins prior to preparation of a CBD distillate. The systems and methods are operable to remove the impurities from the crude oil with a brine solution and at least one acid prior to distillation. The systems and methods are operable with conventional solvents containing between about 5 wt % and about 8 wt % water.

Systems and methods for extracting a compound of interest from plant material, such as a cannabidiol (CBD) from cannabis, are provided. Particularly, the disclosed systems and methods utilize a crude oil to separate water and impurities including fats, sugars, resin glues, chlorophyll, and proteins prior to preparation of a CBD distillate. The systems and methods are operable to remove the impurities from the crude oil with a brine solution and at least one acid prior to distillation. The systems and methods are operable with conventional solvents containing between about 5 wt % and about 8 wt % water.

The present invention provides improved solvents, methods, and systems for isolating purified cannabinoids from various sources. It has been found that C.sub.9 to C.sub.11 non-aromatic hydrocarbon solvents, and especially n-decane, work surprisingly well for crystallization of cannabinoids such as cannabidiol. Some variations provide a method of isolating cannabinoids from a cannabinoid-containing solution, comprising contacting the solution with a C.sub.9-C.sub.11 non-aromatic hydrocarbon solvent (e.g., n-decane) at a first temperature, to generate a mixture; cooling the mixture to precipitate cannabinoids; and isolating the precipitated cannabinoids. Other variations provide a method of isolating cannabinoids from a cannabinoid-containing solution, comprising contacting the solution with a C.sub.9-C.sub.11 non-aromatic hydrocarbon solvent (e.g., n-decane) at a first temperature below the solvent boiling point, to generate a mixture; subjecting the mixture to a second temperature that causes vaporization of the solvent, to precipitate at least some of the cannabinoids; and isolating the precipitated cannabinoids.