Disclosed herein are a method and systems for cumene hydroperoxide cleavage with an improved configuration for online instrumentation. The systems comprise a first fluid loop comprising one or more reactors and a fluid pump and a second fluid loop in fluid communication with the first fluid loop. This second fluid loop comprises an instrument configured to measure a characteristic of a fluid flowing through the second loop, wherein an input of the second fluid loop is disposed downstream of said fluid pump and an output of the second fluid loop is disposed upstream of said fluid pump. The method comprises causing fluid to flow within a first stage comprising one or more reactors and a fluid pump, wherein the first stage is configured to decompose a cumene hydroperoxide in the presence of a catalyst mixture to form a dicumyl peroxide mixture. The method also comprises causing at least a portion of the fluid to flow through a instrumentation line in open fluid communication with the first stage. This instrumentation line comprises an instrument configured to measure a characteristic of the fluid flowing through the instrumentation line and an input of the instrument line is disposed downstream of said fluid pump.

Disclosed herein are a method and systems for cumene hydroperoxide cleavage with an improved configuration for online instrumentation. The systems comprise a first fluid loop comprising one or more reactors and a fluid pump and a second fluid loop in fluid communication with the first fluid loop. This second fluid loop comprises an instrument configured to measure a characteristic of a fluid flowing through the second loop, wherein an input of the second fluid loop is disposed downstream of said fluid pump and an output of the second fluid loop is disposed upstream of said fluid pump. The method comprises causing fluid to flow within a first stage comprising one or more reactors and a fluid pump, wherein the first stage is configured to decompose a cumene hydroperoxide in the presence of a catalyst mixture to form a dicumyl peroxide mixture. The method also comprises causing at least a portion of the fluid to flow through a instrumentation line in open fluid communication with the first stage. This instrumentation line comprises an instrument configured to measure a characteristic of the fluid flowing through the instrumentation line and an input of the instrument line is disposed downstream of said fluid pump.

The disclosure concerns methods comprising forming a phenol and acetone mixture from decomposition of a cumene hydroperoxide or a phenol, acetone, and AMS from the decomposition of a mixture containing dicumyl peroxide in a system comprising one or more reactors where at least a portion of an inner surface of the one or more reactors has a polymer coating and wherein the coating inhibits build-up of a fouling precipitate on the coated inner surface of the one or more reactors as compared to such build-up in the absence of the coating.

The disclosure concerns methods comprising forming a phenol and acetone mixture from decomposition of a cumene hydroperoxide or a phenol, acetone, and AMS from the decomposition of a mixture containing dicumyl peroxide in a system comprising one or more reactors where at least a portion of an inner surface of the one or more reactors has a polymer coating and wherein the coating inhibits build-up of a fouling precipitate on the coated inner surface of the one or more reactors as compared to such build-up in the absence of the coating.

A method for preparing peroxide, including a step of treating, in a reaction medium, a component having at least one tertiary alcohol grouping with a compound having at least one tertiary hydroperoxide function in the presence of a catalyst, said method being characterized in that the catalyst includes a sulphonic acid and a inorganic acid, the molar ratio between the sulphonic acid and the aforementioned component including at least one tertiary alcohol grouping ranges from 0.05 to 0.8, and the molar ratio between the inorganic acid and the aforementioned component including at least one tertiary alcohol grouping ranges from 0.05 to 0.8. Also, to the peroxide resulting directly from said preparation method.

A method for preparing peroxide, including a step of treating, in a reaction medium, a component having at least one tertiary alcohol grouping with a compound having at least one tertiary hydroperoxide function in the presence of a catalyst, said method being characterized in that the catalyst includes a sulphonic acid and a inorganic acid, the molar ratio between the sulphonic acid and the aforementioned component including at least one tertiary alcohol grouping ranges from 0.05 to 0.8, and the molar ratio between the inorganic acid and the aforementioned component including at least one tertiary alcohol grouping ranges from 0.05 to 0.8. Also, to the peroxide resulting directly from said preparation method.

A method for preparing peroxide, including a step of treating, in a reaction medium, a component having at least one tertiary alcohol grouping with a compound having at least one tertiary hydroperoxide function in the presence of a catalyst, said method being characterized in that the catalyst includes a sulphonic acid and a inorganic acid, the molar ratio between the sulphonic acid and the aforementioned component including at least one tertiary alcohol grouping ranges from 0.05 to 0.8, and the molar ratio between the inorganic acid and the aforementioned component including at least one tertiary alcohol grouping ranges from 0.05 to 0.8. Also, to the peroxide resulting directly from said preparation method.

Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.

Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.

Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.