A process for selective oxidation of dimethyl-1,1-biphenyl to form methyl-1,1-biphenyl mono-carboxylic acid(s), comprising contacting a solution of dimethyl-1,1-biphenyl in acetic acid solvent in the presence of a Co(II) acetate catalyst and air, and optionally adding a co-solvent, or adding sodium or potassium acetate, and oxidizing the dimethyl-1,1-biphenyl under time and temperature conditions sufficient to form one or more methyl-1,1-biphenyl mono-carboxylic acid(s). The mono-carboxylic acids are advantageously isolated and esterified to form biphenyl mono-esters for use as plasticizers.

A process for selective oxidation of dimethyl-1,1-biphenyl to form methyl-1,1-biphenyl mono-carboxylic acid(s), comprising contacting a solution of dimethyl-1,1-biphenyl in acetic acid solvent in the presence of a Co(II) acetate catalyst and air, and optionally adding a co-solvent, or adding sodium or potassium acetate, and oxidizing the dimethyl-1,1-biphenyl under time and temperature conditions sufficient to form one or more methyl-1,1-biphenyl mono-carboxylic acid(s). The mono-carboxylic acids are advantageously isolated and esterified to form biphenyl mono-esters for use as plasticizers.

A process for selective oxidation of dimethyl-1,1-biphenyl(s) to form methyl-1,1-biphenyl mono-carboxylic acid(s), which can be esterified to form plasticizers, comprising contacting a solution of dimethyl-1,1-biphenyl(s) in acetic acid in the presence of an oxidation catalyst and air under time and temperature conditions sufficient to oxidize the dimethyl-1,1-biphenyl(s) into one or more methyl-1,1-biphenyl mono-carboxylic acid(s) products, conducting at least one of (i) adding an antisolvent, or (ii) optimizing a total conversion of dimethyl-1,1-biphenyl(s) by oxidation based upon a molar ratio of dimethyl-1,1-biphenyl isomers, or (iii) precipitating the methyl-1,1-biphenyl mono-carboxylic acid(s) products by lowering the temperature, or (iv) decreasing the oxidation reaction temperature to enhance conversion of aldehydes over methyl functional groups, so as to limit over-oxidation of the dimethyl-1,1-biphenyl(s), wherein the oxidation reaction is conducted in the absence of bromide-containing catalysts.

A process for selective oxidation of dimethyl-1,1-biphenyl(s) to form methyl-1,1-biphenyl mono-carboxylic acid(s), which can be esterified to form plasticizers, comprising contacting a solution of dimethyl-1,1-biphenyl(s) in acetic acid in the presence of an oxidation catalyst and air under time and temperature conditions sufficient to oxidize the dimethyl-1,1-biphenyl(s) into one or more methyl-1,1-biphenyl mono-carboxylic acid(s) products, conducting at least one of (i) adding an antisolvent, or (ii) optimizing a total conversion of dimethyl-1,1-biphenyl(s) by oxidation based upon a molar ratio of dimethyl-1,1-biphenyl isomers, or (iii) precipitating the methyl-1,1-biphenyl mono-carboxylic acid(s) products by lowering the temperature, or (iv) decreasing the oxidation reaction temperature to enhance conversion of aldehydes over methyl functional groups, so as to limit over-oxidation of the dimethyl-1,1-biphenyl(s), wherein the oxidation reaction is conducted in the absence of bromide-containing catalysts.

A process for selective oxidation of dimethyl-1,1-biphenyl to form methyl-1,1-biphenyl mono-carboxylic acid(s), comprising contacting a solution of dimethyl-1,1-biphenyl in acetic acid solvent in the presence of a Co(II) acetate catalyst and air, and optionally adding a co-solvent, or adding sodium or potassium acetate, and oxidizing the dimethyl-1,1-biphenyl under time and temperature conditions sufficient to form one or more methyl-1,1-biphenyl mono-carboxylic acid(s). The mono-carboxylic acids are advantageously isolated and esterified to form biphenyl mono-esters for use as plasticizers.

A process for selective oxidation of dimethyl-1,1-biphenyl to form methyl-1,1-biphenyl mono-carboxylic acid(s), comprising contacting a solution of dimethyl-1,1-biphenyl in acetic acid solvent in the presence of a Co(II) acetate catalyst and air, and optionally adding a co-solvent, or adding sodium or potassium acetate, and oxidizing the dimethyl-1,1-biphenyl under time and temperature conditions sufficient to form one or more methyl-1,1-biphenyl mono-carboxylic acid(s). The mono-carboxylic acids are advantageously isolated and esterified to form biphenyl mono-esters for use as plasticizers.

A process for selective oxidation of dimethyl-1,1-biphenyl(s) to form methyl-1,1-biphenyl mono-carboxylic acid(s), which can be esterified to form plasticizers, comprising contacting a solution of dimethyl-1,1-biphenyl(s) in acetic acid in the presence of an oxidation catalyst and air under time and temperature conditions sufficient to oxidize the dimethyl-1,1-biphenyl(s) into one or more methyl-1,1-biphenyl mono-carboxylic acid(s) products, conducting at least one of (i) adding an antisolvent, or (ii) optimizing a total conversion of dimethyl-1,1-biphenyl(s) by oxidation based upon a molar ratio of dimethyl-1,1-biphenyl isomers, or (iii) precipitating the methyl-1,1-biphenyl mono-carboxylic acid(s) products by lowering the temperature, or (iv) decreasing the oxidation reaction temperature to enhance conversion of aldehydes over methyl functional groups, so as to limit over-oxidation of the dimethyl-1,1-biphenyl(s), wherein the oxidation reaction is conducted in the absence of bromide-containing catalysts.

The present invention discloses a method for preparing optically active carbonyl compound, comprising the following steps: under the catalysis of chiral amine salt and transition metal catalysts, with hydrogen and catalytic amount of dihydropyridine compound as hydrogen source, use , -unsaturated aldehydes or , -unsaturated troponoid compounds to conduct asymmetric catalytic reaction to obtain the optically active carbonyl compound. This method comes in moderate reaction condition, simple operation, and catalytic amount of dihydropyridine compounds usage, the target product is easy to be separated and purified from the reaction system, and the metal catalyst can be recycled, it is economical.

The present invention discloses a method for preparing optically active carbonyl compound, comprising the following steps: under the catalysis of chiral amine salt and transition metal catalysts, with hydrogen and catalytic amount of dihydropyridine compound as hydrogen source, use , -unsaturated aldehydes or , -unsaturated troponoid compounds to conduct asymmetric catalytic reaction to obtain the optically active carbonyl compound. This method comes in moderate reaction condition, simple operation, and catalytic amount of dihydropyridine compounds usage, the target product is easy to be separated and purified from the reaction system, and the metal catalyst can be recycled, it is economical.