C07C49/16

Practical Method for Manufacturing 3,3-Difluoro-2-Hydroxypropionic Acid
20180037533 · 2018-02-08 ·

Disclosed is a practical method for production of 3,3-difluoro-2-hydroxypropionic acid, which is important as pharmaceutical and agrichemical intermediates. The method includes forming a 4,4-difluoro-2,2-dichloro-3-oxobutanoic acid ester by reaction of a 4,4-difluoro-3-oxobutanoic acid ester with chlorine (Cl.sub.2), forming 3,3-difluoro-1,1-dichloro-2-propanone by reaction of the chlorination product with an acid, and then, reacting the degradation product with a basic aqueous solution.

Process for preparing C3-6(hydro)fluoroalkenes by dehydrohalogenating C3-6 halo(hydro) fluoroalkanes in the presence of a zinc chromia catalyst

A process for preparing 2,3,3,3-tetrafluoropropene (CF.sub.3CFCH.sub.2). 3,3,3-trifluoro-2-chloropropene (CF.sub.3CClCH.sub.2) is fluorinated with HF in the vapour phase in the presence of a chromia-containing catalyst to produce an intermediate composition 1,1,1,2,2-pentafluoropropane (CF.sub.3CF.sub.2CH.sub.3), which is dehydrofluorinated to produce CF.sub.3CFCH.sub.2.

Process for preparing C3-6(hydro)fluoroalkenes by dehydrohalogenating C3-6 halo(hydro) fluoroalkanes in the presence of a zinc chromia catalyst

A process for preparing 2,3,3,3-tetrafluoropropene (CF.sub.3CFCH.sub.2). 3,3,3-trifluoro-2-chloropropene (CF.sub.3CClCH.sub.2) is fluorinated with HF in the vapour phase in the presence of a chromia-containing catalyst to produce an intermediate composition 1,1,1,2,2-pentafluoropropane (CF.sub.3CF.sub.2CH.sub.3), which is dehydrofluorinated to produce CF.sub.3CFCH.sub.2.

Process for Preparing C3-6(Hydro)Fluoroalkenes by Dehydrohalogenating C3-6 Halo(Hydro) Fluoroalkanes in the Presence of a Zinc Chromia Catalyst

A process for preparing 2,3,3,3-tetrafluoropropene (CF.sub.3CFCH.sub.2). 3,3,3-trifluoro-2-chloropropene (CF.sub.3CClCH.sub.2) is fluorinated with HF in the vapour phase in the presence of a chromia-containing catalyst to produce an intermediate composition 1,1,1,2,2-pentafluoropropane (CF.sub.3CF.sub.2CH.sub.3), which is dehydrofluorinated to produce CF.sub.3CFCH.sub.2.

Process for Preparing C3-6(Hydro)Fluoroalkenes by Dehydrohalogenating C3-6 Halo(Hydro) Fluoroalkanes in the Presence of a Zinc Chromia Catalyst

A process for preparing 2,3,3,3-tetrafluoropropene (CF.sub.3CFCH.sub.2). 3,3,3-trifluoro-2-chloropropene (CF.sub.3CClCH.sub.2) is fluorinated with HF in the vapour phase in the presence of a chromia-containing catalyst to produce an intermediate composition 1,1,1,2,2-pentafluoropropane (CF.sub.3CF.sub.2CH.sub.3), which is dehydrofluorinated to produce CF.sub.3CFCH.sub.2.

Method for producing halogenketones

The present invention describes a novel method for producing haloketones.

Method for producing halogenketones

The present invention describes a novel method for producing haloketones.

Production method for carbonate compound and methacrylate or ester thereof

The present invention relates to a method for producing a carbonate compound and methacrylic acid or an ester thereof, containing a step (a1) of obtaining hexachloroacetone and hydrogen chloride from acetone and chlorine molecule, a step (a2) of obtaining a dialkyl carbonate and chloroform from hexachloroacetone and an alkyl alcohol, a step (b1) of obtaining 1,1,1-trichloro-2-methyl-2-propanol from chloroform and acetone, a step (b2+b3 or b4) of obtaining methacrylic acid or an ester thereof and hydrogen chloride from 1,1,1-trichloro-2-methyl-2-propanol and water or an alcohol, and a step (c1 or c2) of obtaining chlorine molecule by reacting hydrogen chloride with oxygen molecule.

Production method for carbonate compound and methacrylate or ester thereof

The present invention relates to a method for producing a carbonate compound and methacrylic acid or an ester thereof, containing a step (a1) of obtaining hexachloroacetone and hydrogen chloride from acetone and chlorine molecule, a step (a2) of obtaining a dialkyl carbonate and chloroform from hexachloroacetone and an alkyl alcohol, a step (b1) of obtaining 1,1,1-trichloro-2-methyl-2-propanol from chloroform and acetone, a step (b2+b3 or b4) of obtaining methacrylic acid or an ester thereof and hydrogen chloride from 1,1,1-trichloro-2-methyl-2-propanol and water or an alcohol, and a step (c1 or c2) of obtaining chlorine molecule by reacting hydrogen chloride with oxygen molecule.

Process for preparing C3-6(hydro)fluoroalkenes by dehydrohalogenating C3-6 halo(hydro)fluoroalkanes in the presence of a zinc/chromia catalyst

The invention relates to a process for preparing a C3-6 (hydro)fluoroalkene comprising dehydrohalogenating a C3-6 hydro(halo)fluoroalkane in the presence of a zinc/chromia catalyst, wherein the Ccustom character3-6 (hydro)fluoroalkene produced is isomerized in the presence of the zinc/chromia catalyst.