CB-7 exhibits a weak TLR7 inhibiting effect in normal mice. The present invention provides a novel compound with a stronger TLR7 inhibiting effect than CB-7, a pharmaceutically acceptable salt of said compound, or a prodrug of said compound or salt. The present invention also provides a drug for the prevention or treatment of diseases associated with the activation of TLR7, said drug including the aforementioned TLR7 activation inhibitor.

CB-7 exhibits a weak TLR7 inhibiting effect in normal mice. The present invention provides a novel compound with a stronger TLR7 inhibiting effect than CB-7, a pharmaceutically acceptable salt of said compound, or a prodrug of said compound or salt. The present invention also provides a drug for the prevention or treatment of diseases associated with the activation of TLR7, said drug including the aforementioned TLR7 activation inhibitor.

A charge transport molecule contains four radical polymerizable functional groups of the general structure exemplified below: ##STR00001##
where R.sub.1 and R.sub.2 contain a spacer group and a radical polymerizable functional group, R.sub.3 and R.sub.4 are hydrogen atoms, and R.sub.5 and R.sub.6 contain a spacer group and a radical polymerizable functional group wherein the spacer group of R.sub.1, R.sub.2, R.sub.5 and R.sub.6 is an ethyl group and the radical polymerizable functional group of R.sub.1, R.sub.2, R.sub.5 and R.sub.6 is an acrylate group.

A charge transport molecule contains four radical polymerizable functional groups of the general structure exemplified below: ##STR00001##
where R.sub.1 and R.sub.2 contain a spacer group and a radical polymerizable functional group, R.sub.3 and R.sub.4 are hydrogen atoms, and R.sub.5 and R.sub.6 contain a spacer group and a radical polymerizable functional group wherein the spacer group of R.sub.1, R.sub.2, R.sub.5 and R.sub.6 is an ethyl group and the radical polymerizable functional group of R.sub.1, R.sub.2, R.sub.5 and R.sub.6 is an acrylate group.

An overcoat layer for an organic photoconductor drum includes a curable composition having about 20 to about 80 percent by weight of a charge transport molecule containing four radical polymerizable functional groups as exemplified below: ##STR00001##
where R.sub.1 and R.sub.2 contain a spacer group and a radical polymerizable functional group, R.sub.3 and R.sub.4 are hydrogen atoms, and R.sub.5 and R.sub.6 contain a spacer group and a radical polymerizable functional group. The curable composition may also include a non-radical polymerizable additive, such as a surfactant, and/or a curing agent.

An overcoat layer for an organic photoconductor drum includes a curable composition having about 20 to about 80 percent by weight of a charge transport molecule containing four radical polymerizable functional groups as exemplified below:

##STR00001##

where R.sub.1 and R.sub.2 contain a spacer group and a radical polymerizable functional group, R.sub.3 and R.sub.4 are hydrogen atoms, and R.sub.5 and R.sub.6 contain a spacer group and a radical polymerizable functional group. The curable composition may also include a non-radical polymerizable additive, such as a surfactant, and/or a curing agent.

An organic photoconductor drum includes a support element, a charge generation layer over the support element, a charge transport layer over the charge generation layer, and an overcoat layer. The overcoat layer includes a curable composition having both a non-radical polymerizable additive and a charge transport molecule containing four radical polymerizable functional groups exemplified as:

##STR00001##

where R.sub.1 and R.sub.2 contain a spacer group and a radical polymerizable functional group, R.sub.3 and R.sub.4 are hydrogen atoms, and R.sub.5 and R.sub.6 contain a spacer group and a radical polymerizable functional group wherein the spacer group of R.sub.1, R.sub.2, R.sub.5, and R.sub.6, is an ethyl group and the radical polymerizable functional group of R.sub.1, R.sub.2, R.sub.5 and R.sub.6 is an acrylate group. The non-radical polymerizable additive may be a surfactant. The curable composition may also include a curing agent.

A charge transport molecule contains four radical polymerizable functional groups of the general structure exemplified below:

##STR00001##

where R.sub.1 and R.sub.2 contain a spacer group and a radical polymerizable functional group, R.sub.3 and R.sub.4 are hydrogen atoms, and R.sub.5 and R.sub.6 contain a spacer group and a radical polymerizable functional group wherein the spacer group of R.sub.1, R.sub.2, R.sub.5 and R.sub.6 is an ethyl group and the radical polymerizable functional group of R.sub.1, R.sub.2, R.sub.5 and R.sub.6 is an acrylate group.

A method for preparing a multi-substituted acrylic acid compound includes steps as follow. A reaction solution is provided, wherein the reaction solution includes an organometallic reagent, a nickel-containing metal catalyst, a catalyst ligand, a first solvent, and the organometallic reagent is a Grignard reagent or a Gilman reagent. An addition step is conducted, wherein an alkyne compound is mixed with the reaction solution so as to undergo an addition reaction, thus an intermediate solution is obtained. A substitution step is conducted, wherein a carbon dioxide is introduced into the intermediate solution so as to obtain the multi-substituted acrylic acid compound.

A method for preparing a multi-substituted acrylic acid compound includes steps as follow. A reaction solution is provided, wherein the reaction solution includes an organometallic reagent, a nickel-containing metal catalyst, a catalyst ligand, a first solvent, and the organometallic reagent is a Grignard reagent or a Gilman reagent. An addition step is conducted, wherein an alkyne compound is mixed with the reaction solution so as to undergo an addition reaction, thus an intermediate solution is obtained. A substitution step is conducted, wherein a carbon dioxide is introduced into the intermediate solution so as to obtain the multi-substituted acrylic acid compound.