Patent classifications
C07C59/64
IMIQUIMOD COCRYSTALS
The invention relates to novel crystalline forms of imiquimod formed with ferulic acid, acetic acid, coumaric acid, citric acid, or tartaric acid, to methods of making these cocrystals, and to compositions containing the cocrystals.
PROCESSES AND INTERMEDIATES FOR PREPARING alpha,omega-DICARBOXYLIC ACID-TERMINATED DIALKENE ETHERS
The present disclosure provides a process for the preparation of compounds of formula (III),
##STR00001##
compounds of formula (V),
##STR00002##
and corresponding salts of formula (IV).
##STR00003##
The compounds made by the methods and processes of the invention are particularly useful for administration in humans and animals.
PROCESSES AND INTERMEDIATES FOR PREPARING alpha,omega-DICARBOXYLIC ACID-TERMINATED DIALKENE ETHERS
The present disclosure provides a process for the preparation of compounds of formula (III),
##STR00001##
compounds of formula (V),
##STR00002##
and corresponding salts of formula (IV).
##STR00003##
The compounds made by the methods and processes of the invention are particularly useful for administration in humans and animals.
CO-CRYSTALS OF TRAMADOL AND COXIBS
The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
CO-CRYSTALS OF TRAMADOL AND COXIBS
The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
2-BETA-NAPHTHYL-ACETIC ACID ANALOGS AS AKR1C3 INHIBITORS AND METHODS OF USING SAME
The invention includes 2-β-naphthyl-acetic acid derivatives, which are selective AKR1C3 inhibitors. In certain embodiments, the compounds of the invention are R-naproxen analogs. The invention further includes methods of treating cancer, such as prostate cancer and/or castration-resistant prostate cancer, using at least one compound of the invention.
2-BETA-NAPHTHYL-ACETIC ACID ANALOGS AS AKR1C3 INHIBITORS AND METHODS OF USING SAME
The invention includes 2-β-naphthyl-acetic acid derivatives, which are selective AKR1C3 inhibitors. In certain embodiments, the compounds of the invention are R-naproxen analogs. The invention further includes methods of treating cancer, such as prostate cancer and/or castration-resistant prostate cancer, using at least one compound of the invention.
Co-crystals of tramadol and coxibs
The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
Co-crystals of tramadol and coxibs
The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
USE OF HYDROXYCINNAMIC ACID SALTS FOR STABILIZING ORGANIC MATERIALS, STABILIZED ORGANIC MATERIAL, METHOD FOR STABILIZING ORGANIC MATERIALS, SPECIFIC STABILIZERS AND STABILIZER COMPOSITIONS
The invention relates to the use of specific hydroycinnamic acid salts for stabilizing organic materials. The invention also relates to a corresponding organic material stabilized by incorporating a specific hydroxycinnamic acid salt, and to a method for stabilizing organic materials. In addition, a specific aluminum salt of a hydroxycinnamic acid suitable as an organic stabilizer is described. The invention further relates to a stabilizer composition comprising a corresponding hydroxycinnamic acid salt.