Patent classifications
C07D213/56
Amide compounds as kinase inhibitors, compositions and methods of treatment
The present disclosure relates to certain amides and heterocyclic compounds and uses of these amides and heterocyclic compounds to inhibit Rho-associated protein kinases and treat diseases including autoimmune disorders, graft versus host disease (GVHD), inflammation, cardiovascular disorders, central nervous system disorders, and neoplastic disorders.
Amide compounds as kinase inhibitors, compositions and methods of treatment
The present disclosure relates to certain amides and heterocyclic compounds and uses of these amides and heterocyclic compounds to inhibit Rho-associated protein kinases and treat diseases including autoimmune disorders, graft versus host disease (GVHD), inflammation, cardiovascular disorders, central nervous system disorders, and neoplastic disorders.
Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
- Joseph D. Eckelbarger ,
- Daniel I. Knueppel ,
- Ronald J. Heemstra ,
- Ronald Ross, Jr. ,
- Kyle A. DeKorver ,
- Kaitlyn Gray ,
- Peter Vednor ,
- Timothy P. Martin ,
- Ricky Hunter ,
- David A. Demeter ,
- Tony K. Trullinger ,
- Erich W. Baum ,
- Zoltan L. Benko ,
- Nakyen Choy ,
- Gary D. Crouse ,
- John F. Daeuble, SR. ,
- Fangzheng Li ,
- Jeffrey Nissen ,
- Michelle Riener ,
- Thomas C. Sparks ,
- Frank J. Wessels ,
- Maurice C. Yap
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
##STR00001##
Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
- Joseph D. Eckelbarger ,
- Daniel I. Knueppel ,
- Ronald J. Heemstra ,
- Ronald Ross, Jr. ,
- Kyle A. DeKorver ,
- Kaitlyn Gray ,
- Peter Vednor ,
- Timothy P. Martin ,
- Ricky Hunter ,
- David A. Demeter ,
- Tony K. Trullinger ,
- Erich W. Baum ,
- Zoltan L. Benko ,
- Nakyen Choy ,
- Gary D. Crouse ,
- John F. Daeuble, SR. ,
- Fangzheng Li ,
- Jeffrey Nissen ,
- Michelle Riener ,
- Thomas C. Sparks ,
- Frank J. Wessels ,
- Maurice C. Yap
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
##STR00001##
TRICYCLIC SPIRO COMPOUND
A medicinal agent for the prevention and/or treatment of diseases caused by EP.sub.4 receptor activation. A compound having antagonistic activity against the EP.sub.4 receptor is contained as an active ingredient in the medicinal agent. The compound represented by the following general formula (I) as defined in the specification, a salt, an N-oxide, or a solvate thereof, or a prodrug of these is useful as a medicinal component having antagonistic activity against the EP.sub.4 receptor for the prevention and/or treatment of diseases caused by EP.sub.4 receptor activation.
##STR00001##
Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
- Timothy P. Martin ,
- Joseph D. Eckelbarger ,
- Ronald Ross, Jr. ,
- Kyle A. DeKorver ,
- Ronald J. Heemstra ,
- Daniel I. Knueppel ,
- Peter Vednor ,
- Ricky Hunter ,
- David A. Demeter ,
- Tony K. Trullinger ,
- Erich W. Baum ,
- Zoltan L. Benko ,
- Nakyen Choy ,
- Gary D. Crouse ,
- John F. Daeuble, SR. ,
- Fangzheng Li ,
- Jeffrey Nissen ,
- Michelle Riener ,
- Thomas C. Sparks ,
- Frank J. Wessels ,
- Maurice C. Yap
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
##STR00001##
Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
- Timothy P. Martin ,
- Joseph D. Eckelbarger ,
- Ronald Ross, Jr. ,
- Kyle A. DeKorver ,
- Ronald J. Heemstra ,
- Daniel I. Knueppel ,
- Peter Vednor ,
- Ricky Hunter ,
- David A. Demeter ,
- Tony K. Trullinger ,
- Erich W. Baum ,
- Zoltan L. Benko ,
- Nakyen Choy ,
- Gary D. Crouse ,
- John F. Daeuble, SR. ,
- Fangzheng Li ,
- Jeffrey Nissen ,
- Michelle Riener ,
- Thomas C. Sparks ,
- Frank J. Wessels ,
- Maurice C. Yap
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
##STR00001##
GPR52 MODULATORS AND METHODS OF USE
The present disclosure relates to compounds of Formula (I) that modulate the activity of G-protein coupled receptor 52 (GPR52), pharmaceutically acceptable salts of compounds of Formula (I), and pharmaceutical compositions thereof. Compounds, pharmaceutical salts of compounds, and pharmaceutical compositions of the present disclosure are directed to methods useful in the treatment or prophylaxis of a neurological disease or disorder and conditions related thereto.
##STR00001##
GPR52 MODULATORS AND METHODS OF USE
The present disclosure relates to compounds of Formula (I) that modulate the activity of G-protein coupled receptor 52 (GPR52), pharmaceutically acceptable salts of compounds of Formula (I), and pharmaceutical compositions thereof. Compounds, pharmaceutical salts of compounds, and pharmaceutical compositions of the present disclosure are directed to methods useful in the treatment or prophylaxis of a neurological disease or disorder and conditions related thereto.
##STR00001##
PHOTOPOLYMERIZABLE ANTIBACTERIAL MONOMER
The present invention relates to a compound having antibacterial properties suitable for use as an antibacterial monomer, a photopolymerizable composition which includes said compound, and use thereof in a dental procedure.