Provided herein is a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof, using cynamide in the reaction.

##STR00001##

Provided herein is a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof, using cynamide in the reaction.

##STR00001##

The invention relates to the novel products of formula (I): ##STR00001##
with p, q=0, 1 or 2; R1=phenyl, pyridyl; —(CH.sub.2).sub.m—Ra; alkylene; cycloalkyl; heterocycloalkyl; alkyl; —SO.sub.2—Rb; —CO—Re; m=1 or 2; Ra=aryl, heteroaryl, —CO-cycloalkyl, —CO-heterocycloalkyl, —CO—Rb, —C(Rb)═N—ORc, —CO.sub.2Rd, —CONRxRy; Rb=alkyl, aryl, heteroaryl; Rc=H, alkyl; Rd=alkyl, cycloalkyl; Re=alkyl, cycloalkyl, aryl, heteroaryl; NRxRy with Rx,Ry=H, alkyl, cycloalkyl, alkoxy, phenyl, or form with N a ring with optionally O, N; R2, R3=H, alkyl, CF.sub.3, or form with C a ring with optionally O, S and N; R4=H, F, Cl, CH.sub.3 or CN; the morpholine is substituted with Me, and optionally substituted with F, OH; or is ##STR00002##
and the isomer of configuration R,R ##STR00003##
these products being in all the isomer forms and the salts, as medicaments, in particular as anticancer medicaments.

The invention relates to the novel products of formula (I): ##STR00001##
with p, q=0, 1 or 2; R1=phenyl, pyridyl; —(CH.sub.2).sub.m—Ra; alkylene; cycloalkyl; heterocycloalkyl; alkyl; —SO.sub.2—Rb; —CO—Re; m=1 or 2; Ra=aryl, heteroaryl, —CO-cycloalkyl, —CO-heterocycloalkyl, —CO—Rb, —C(Rb)═N—ORc, —CO.sub.2Rd, —CONRxRy; Rb=alkyl, aryl, heteroaryl; Rc=H, alkyl; Rd=alkyl, cycloalkyl; Re=alkyl, cycloalkyl, aryl, heteroaryl; NRxRy with Rx,Ry=H, alkyl, cycloalkyl, alkoxy, phenyl, or form with N a ring with optionally O, N; R2, R3=H, alkyl, CF.sub.3, or form with C a ring with optionally O, S and N; R4=H, F, Cl, CH.sub.3 or CN; the morpholine is substituted with Me, and optionally substituted with F, OH; or is ##STR00002##
and the isomer of configuration R,R ##STR00003##
these products being in all the isomer forms and the salts, as medicaments, in particular as anticancer medicaments.

Provided are novel bis-cyclic guanidine compounds, and the use thereof for treating bacterial infection.

Provided are novel bis-cyclic guanidine compounds, and the use thereof for treating bacterial infection.

Provided are novel bis-cyclic guanidine compounds, and the use thereof for treating bacterial infection.

Provided are novel bis-cyclic guanidine compounds, and the use thereof for treating bacterial infection.

Provided are novel bis-cyclic guanidine compounds, and the use thereof for treating bacterial infection.

Provided are novel bis-cyclic guanidine compounds, and the use thereof for treating bacterial infection.