Patent classifications
C07D233/46
CHIRAL GUANIDINES, SALTS THEREOF, METHODS OF MAKING CHIRAL GUANIDINES AND SALTS THEREOF, AND USES OF CHIRAL GUANIDINES AND SALTS THEREOF IN THE PREPARATION OF ENANTIOMERICALLY PURE AMINO ACIDS
Provided are compounds and salts having a structure of Formula (I) or (II): (I), and (II) wherein: both of the chiral carbon atoms denoted by “*” are both in the R configuration or both in the S configuration. Compounds and salts of Formulae (I) and (II) are useful in the preparation of enantiomerically pure amino acids. Conversion of amino acids to D-form from any of L-form, racemate or other enantiomerically impure mixtures or conversion of amino acids to L-form from any of D-form, racemate or other enantiomerically impure mixtures is disclosed.
##STR00001##
CHIRAL GUANIDINES, SALTS THEREOF, METHODS OF MAKING CHIRAL GUANIDINES AND SALTS THEREOF, AND USES OF CHIRAL GUANIDINES AND SALTS THEREOF IN THE PREPARATION OF ENANTIOMERICALLY PURE AMINO ACIDS
Provided are compounds and salts having a structure of Formula (I) or (II): (I), and (II) wherein: both of the chiral carbon atoms denoted by “*” are both in the R configuration or both in the S configuration. Compounds and salts of Formulae (I) and (II) are useful in the preparation of enantiomerically pure amino acids. Conversion of amino acids to D-form from any of L-form, racemate or other enantiomerically impure mixtures or conversion of amino acids to L-form from any of D-form, racemate or other enantiomerically impure mixtures is disclosed.
##STR00001##
HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
Hydantoin containing deoxyuridine triphosphatase inhibitors
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
Hydantoin containing deoxyuridine triphosphatase inhibitors
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS
The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in .sup.18F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.
COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS
The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in .sup.18F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.
HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.