The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S.sub.1P.sub.1 receptor and methods of using the same.

The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.

The present disclosure provides methods for producing N-(fluorosulfonyl)azoles, sulfonyldiazoles, or related derivatives thereof, and the related products including N-(fluorosulfonyl)azoles, sulfonyldiazoles, and related derivatives thereof. For example, an N-(fluorosulfonyl)azole is obtained by reaction of sulfuryl fluoride with an azoles, an azolate salt, an N-silylazole, or a combination thereof. Symmetric and asymmetric sulfonyldiazoles are obtained by further reaction of such an N-(fluorosulfonyl)azole with azoles, azolate salts, or N-silylazoles. A sulfonyldiazole can be also produced by reacting sulfuryl fluoride with an azole, an N-silylazole, or a combination thereof in one pot.

The present disclosure provides methods for producing N-(fluorosulfonyl)azoles, sulfonyldiazoles, or related derivatives thereof, and the related products including N-(fluorosulfonyl)azoles, sulfonyldiazoles, and related derivatives thereof. For example, an N-(fluorosulfonyl)azole is obtained by reaction of sulfuryl fluoride with an azoles, an azolate salt, an N-silylazole, or a combination thereof. Symmetric and asymmetric sulfonyldiazoles are obtained by further reaction of such an N-(fluorosulfonyl)azole with azoles, azolate salts, or N-silylazoles. A sulfonyldiazole can be also produced by reacting sulfuryl fluoride with an azole, an N-silylazole, or a combination thereof in one pot.

The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.

The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.

The present invention provides a hydraulic fluid comprising: (a) 40 to 2000 ppm by weight in terms of nitrogen content of a corrosion inhibiting agent which is one or more compounds of formula (I):

##STR00001## and/or tribologically acceptable salts thereof, wherein in formula (I): each R.sup.1 is independently a hydrocarbyl group comprising 1 to 10 carbon atoms, x is 0 to 4, each of R.sup.2 and R.sup.3 is independently hydrogen or a hydrocarbyl group comprising 1 to 20 carbon atoms, R.sup.4 is —NR.sup.5R.sup.6 or —OR.sup.7, each of R.sup.5 and R.sup.6 is independently an aryl group comprising 6 to 14 carbon atoms, optionally substituted with one or more hydrocarbyl groups comprising 1 to 20 carbon atoms, R.sup.7 is a hydrocarbyl group comprising 1 to 20 carbon atoms, and in each of said hydrocarbyl groups containing 2 or more carbon atoms, the carbon chain may, independently, optionally be interrupted by one or more ether groups; (b) 0.1 to 1% by weight of an ashless dispersant; and (c) a major amount of a base oil.

The present invention provides a hydraulic fluid comprising: (a) 40 to 2000 ppm by weight in terms of nitrogen content of a corrosion inhibiting agent which is one or more compounds of formula (I):

##STR00001## and/or tribologically acceptable salts thereof, wherein in formula (I): each R.sup.1 is independently a hydrocarbyl group comprising 1 to 10 carbon atoms, x is 0 to 4, each of R.sup.2 and R.sup.3 is independently hydrogen or a hydrocarbyl group comprising 1 to 20 carbon atoms, R.sup.4 is —NR.sup.5R.sup.6 or —OR.sup.7, each of R.sup.5 and R.sup.6 is independently an aryl group comprising 6 to 14 carbon atoms, optionally substituted with one or more hydrocarbyl groups comprising 1 to 20 carbon atoms, R.sup.7 is a hydrocarbyl group comprising 1 to 20 carbon atoms, and in each of said hydrocarbyl groups containing 2 or more carbon atoms, the carbon chain may, independently, optionally be interrupted by one or more ether groups; (b) 0.1 to 1% by weight of an ashless dispersant; and (c) a major amount of a base oil.

Substituted aromatic sulfonamides of formula (I)

##STR00001##

pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.

Substituted aromatic sulfonamides of formula (I)

##STR00001##

pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.