Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of ##STR00001## wherein R.sup.1 is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl; R.sup.2 is NHC(O)R.sup.3-L or C(O)NHR.sup.3-L, wherein R.sup.3 is an aryl or an aliphatic group (such as alkyl); each R.sup.4 independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R.sup.5 independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R.sup.4; each n independently is 1, 2, 3, 4, or 5; and L is .sup.18F or a chelator capable of chelating a radiolabel (such as chelators for [.sup.18F]AlF, .sup.64Cu, .sup.68Ga), 1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).

Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of ##STR00001## wherein R.sup.1 is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl; R.sup.2 is NHC(O)R.sup.3-L or C(O)NHR.sup.3-L, wherein R.sup.3 is an aryl or an aliphatic group (such as alkyl); each R.sup.4 independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R.sup.5 independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R.sup.4; each n independently is 1, 2, 3, 4, or 5; and L is .sup.18F or a chelator capable of chelating a radiolabel (such as chelators for [.sup.18F]AlF, .sup.64Cu, .sup.68Ga), 1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).

The present invention is directed to bifunctional compounds which are useful in the treatment of fungal infections. The present compounds contains at least one fungal binding moiety (FBM) which is linked to at least one antibody binding moiety (A.sub.BM or ABT group) through a linker group, which optionally comprises a connector group. Compounds according to the present invention are useful in the treatment of fungal infections as described herein.

The present invention is directed to bifunctional compounds which are useful in the treatment of fungal infections. The present compounds contains at least one fungal binding moiety (FBM) which is linked to at least one antibody binding moiety (A.sub.BM or ABT group) through a linker group, which optionally comprises a connector group. Compounds according to the present invention are useful in the treatment of fungal infections as described herein.

The disclosure pertains to urea production with, in series, an MP carbamate condenser for condensing at least urea synthesis section off-gas, gas/liquid separation giving a gas stream and a liquid stream, and a second carbamate condenser receiving off-gas from melamine production and said liquid stream.

Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of

##STR00001##

wherein R.sup.1 is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl; R.sup.2 is NHC(O)R.sup.3-L or C(O)NHR.sup.3-L, wherein R.sup.3 is an aryl or an aliphatic group (such as alkyl); each R.sup.4 independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R.sup.5 independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R.sup.4; each n independently is 1, 2, 3, 4, or 5; and L is .sup.18F or a chelator capable of chelating a radiolabel (such as chelators for [.sup.18F]AlF, .sup.64Cu, .sup.68Ga), 1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).

Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of

##STR00001##

wherein R.sup.1 is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl; R.sup.2 is NHC(O)R.sup.3-L or C(O)NHR.sup.3-L, wherein R.sup.3 is an aryl or an aliphatic group (such as alkyl); each R.sup.4 independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R.sup.5 independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R.sup.4; each n independently is 1, 2, 3, 4, or 5; and L is .sup.18F or a chelator capable of chelating a radiolabel (such as chelators for [.sup.18F]AlF, .sup.64Cu, .sup.68Ga), 1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).

The instant invention relates to mixed salts of optical brighteners of formula (1), ##STR00001##
wherein M represents a mixture of Mg.sup.2+ with another cation, which provide for superior optical brightening effects when applied to the surface of paper.

Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of ##STR00001## wherein R.sup.1 is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl; R.sup.2 is NHC(O)R.sup.3L or C(O)NHR.sup.3L, wherein R.sup.3 is an aryl or an aliphatic group (such as alkyl); each R.sup.4 independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R.sup.5 independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R.sup.4; each n independently is 1, 2, 3, 4, or 5; and L is .sup.18F or a chelator capable of chelating a radiolabel (such as chelators for [.sup.18F]AlF, .sup.64Cu, .sup.68Ga),1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).

Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of ##STR00001## wherein R.sup.1 is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl; R.sup.2 is NHC(O)R.sup.3L or C(O)NHR.sup.3L, wherein R.sup.3 is an aryl or an aliphatic group (such as alkyl); each R.sup.4 independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R.sup.5 independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R.sup.4; each n independently is 1, 2, 3, 4, or 5; and L is .sup.18F or a chelator capable of chelating a radiolabel (such as chelators for [.sup.18F]AlF, .sup.64Cu, .sup.68Ga),1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).