Patent classifications
C07D311/36
Processes for the preparation of <i>ortho</i>-allylated hydroxy aryl compounds
The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I). ##STR00001##
Process for preparation of optically pure and optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives and their use in preparing pharmaceuticals
The present invention relates to compounds useful as pharmaceutical intermediates, to processes for preparing the intermediates, to intermediates used in the processes, and to the use of the intermediates in the preparation of pharmaceuticals. In particular, the present invention concerns enantiomerically pure optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives represented by formula (IA) and (IB), processes for preparing the alcohol derivatives and their use in preparing pharmaceuticals.
Process for preparation of optically pure and optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives and their use in preparing pharmaceuticals
The present invention relates to compounds useful as pharmaceutical intermediates, to processes for preparing the intermediates, to intermediates used in the processes, and to the use of the intermediates in the preparation of pharmaceuticals. In particular, the present invention concerns enantiomerically pure optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives represented by formula (IA) and (IB), processes for preparing the alcohol derivatives and their use in preparing pharmaceuticals.
METHOD FOR CHLORINATING BLUE ANTHRONE, VIOLANTHRONE OR ISOVIOLANTRONE
A method for chlorinating blue anthrone, violanthrone or isoviolanthrone is provided. Reaction is carried out with a chlorinating agent (any one of sulfonyl chloride, thionyl chloride and triphosgene) in a reaction solvent (a Lewis acid ionic liquid with anions being of a transition metal halide) for 2 h to 40 h at a chlorination temperature not lower than room temperature and not higher than 120° C.; and then the reaction product is subjected to post-treatment to obtain a target product. The present disclosure cuts off a generation route of harmful substances such as dioxins and their derivatives from the source. There are no dioxins or similar substances generated in the product, and the reaction has high atomic utilization rate and low energy consumption, which fills the gap in the field of chemical technologies at home and abroad.
METHOD FOR CHLORINATING BLUE ANTHRONE, VIOLANTHRONE OR ISOVIOLANTRONE
A method for chlorinating blue anthrone, violanthrone or isoviolanthrone is provided. Reaction is carried out with a chlorinating agent (any one of sulfonyl chloride, thionyl chloride and triphosgene) in a reaction solvent (a Lewis acid ionic liquid with anions being of a transition metal halide) for 2 h to 40 h at a chlorination temperature not lower than room temperature and not higher than 120° C.; and then the reaction product is subjected to post-treatment to obtain a target product. The present disclosure cuts off a generation route of harmful substances such as dioxins and their derivatives from the source. There are no dioxins or similar substances generated in the product, and the reaction has high atomic utilization rate and low energy consumption, which fills the gap in the field of chemical technologies at home and abroad.
PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS
The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).
##STR00001##
Compounds as modulators of protein kinases
The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.
Compounds as modulators of protein kinases
The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.
Chromone inhibitors of S-nitrosoglutathione reductase
The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
Chromone inhibitors of S-nitrosoglutathione reductase
The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.