Probes for the detection of β-lactamase-type enzymatic activity. In particular, novel fluorogenic substrates for detecting the presence of a catalytically active β-lactamase and a detection method using such substrates.

Probes for the detection of β-lactamase-type enzymatic activity. In particular, novel fluorogenic substrates for detecting the presence of a catalytically active β-lactamase and a detection method using such substrates.

Described herein is a synergistic combination comprising a quorum-sensing inhibitor and/or postbiotic metabolite and an antibiotic. Typically, the postbiotic metabolite comprises at least one peptide. Related compositions, uses, and methods are also described, including methods for resensitizing resistant bacteria to an antibiotic, and methods of treating antibiotic-resistant infections, such as methicillin-resistant Staphylococcus aureus (MRSA).

This disclosure provides multifunctional conjugate molecules in which at least one β-lactam antibiotic is covalently attached to a cannabinoid by means of a linker. The disclosed conjugate molecules are designed to deliver therapeutic benefits as intact molecules, with release of the cannabinoid upon binding of the β-lactam antibiotic to its target conveying further therapeutic benefits, and can be used to treat bacterial infections and other disorders.

The present invention relates to a crystal of cephalosporin intermediate 7-methoxy cephalothin (I) and a method for preparing same. The crystal of 7-methoxy cephalothin (I) undergoes Cu-Ka radiation and X-ray powder diffraction expressed in terms of angle 2; the crystal of 7-methoxy cephalothin (I) has characteristic absorption peaks at positions of 7.340.20, 12.710.20, 14.250.20, 14.680.20, 16.520.20, 17.990.20, 19.980.20, and 22.690.20. The crystal of 7-methoxy cephalothin provided by the present invention is easy to prepare. Related test data shows that the crystal of 7-methoxy cephalothin has high purity, low impurity content, and good stability. The preparation cost is low, the preparation method is simple to operate, conditions are mild and easy to control, and crystals of 7-methoxy cephalothin can be obtained stably. The invention is applicable to industrial production.

The present invention relates to a crystal of cephalosporin intermediate 7-methoxy cephalothin (I) and a method for preparing same. The crystal of 7-methoxy cephalothin (I) undergoes Cu-Ka radiation and X-ray powder diffraction expressed in terms of angle 2; the crystal of 7-methoxy cephalothin (I) has characteristic absorption peaks at positions of 7.340.20, 12.710.20, 14.250.20, 14.680.20, 16.520.20, 17.990.20, 19.980.20, and 22.690.20. The crystal of 7-methoxy cephalothin provided by the present invention is easy to prepare. Related test data shows that the crystal of 7-methoxy cephalothin has high purity, low impurity content, and good stability. The preparation cost is low, the preparation method is simple to operate, conditions are mild and easy to control, and crystals of 7-methoxy cephalothin can be obtained stably. The invention is applicable to industrial production.

The present invention relates to a crystal of cephalosporin intermediate 7-methoxy cephalothin (I) and a method for preparing same. The crystal of 7-methoxy cephalothin (I) undergoes Cu-Ka radiation and X-ray powder diffraction expressed in terms of angle 2; the crystal of 7-methoxy cephalothin (I) has characteristic absorption peaks at positions of 7.340.20, 12.710.20, 14.250.20, 14.680.20, 16.520.20, 17.990.20, 19.980.20, and 22.690.20. The crystal of 7-methoxy cephalothin provided by the present invention is easy to prepare. Related test data shows that the crystal of 7-methoxy cephalothin has high purity, low impurity content, and good stability. The preparation cost is low, the preparation method is simple to operate, conditions are mild and easy to control, and crystals of 7-methoxy cephalothin can be obtained stably. The invention is applicable to industrial production.

The present invention relates to a crystal of cephalosporin intermediate 7-methoxy cephalothin (I) and a method for preparing same. The crystal of 7-methoxy cephalothin (I) undergoes Cu-Ka radiation and X-ray powder diffraction expressed in terms of angle 2; the crystal of 7-methoxy cephalothin (I) has characteristic absorption peaks at positions of 7.340.20, 12.710.20, 14.250.20, 14.680.20, 16.520.20, 17.990.20, 19.980.20, and 22.690.20. The crystal of 7-methoxy cephalothin provided by the present invention is easy to prepare. Related test data shows that the crystal of 7-methoxy cephalothin has high purity, low impurity content, and good stability. The preparation cost is low, the preparation method is simple to operate, conditions are mild and easy to control, and crystals of 7-methoxy cephalothin can be obtained stably. The invention is applicable to industrial production.

-Lactamase substrates and methods for using the substrates to detect -lactamase diagnose tuberculosis.

-Lactamase substrates and methods for using the substrates to detect -lactamase diagnose tuberculosis.