Patent classifications
C07D501/52
2,7-disubstituted cephalosporin derivatives as beta-lactamase substrates and methods for their use for the diagnosis of tuberculosis
β-Lactamase substrates and methods for using the substrates to detect β-lactamase and to diagnose tuberculosis.
2,7-disubstituted cephalosporin derivatives as beta-lactamase substrates and methods for their use for the diagnosis of tuberculosis
β-Lactamase substrates and methods for using the substrates to detect β-lactamase and to diagnose tuberculosis.
Photoactivatable antimicrobial agents and therapeutic and diagnostic methods of using same
The present invention provides photosensitizer compounds for use in detecting beta-lactamase activity. Methods and kits that utilize the photosensitizer compounds of the invention for the detection of, quantitation of, and classification or typing of microbial beta-lactamases.
Photoactivatable antimicrobial agents and therapeutic and diagnostic methods of using same
The present invention provides photosensitizer compounds for use in detecting beta-lactamase activity. Methods and kits that utilize the photosensitizer compounds of the invention for the detection of, quantitation of, and classification or typing of microbial beta-lactamases.
Photoactivatable antimicrobial agents and therapeutic and diagnostic methods of using same
The present invention provides photosensitizer compounds for use in detecting beta-lactamase activity. Methods and kits that utilize the photosensitizer compounds of the invention for the detection of, quantitation of, and classification or typing of microbial beta-lactamases.
Photoactivatable antimicrobial agents and therapeutic and diagnostic methods of using same
The present invention provides photosensitizer compounds for use in detecting beta-lactamase activity. Methods and kits that utilize the photosensitizer compounds of the invention for the detection of, quantitation of, and classification or typing of microbial beta-lactamases.
Antimicrobial prochelators to target drug-resistant bacteria and methods of making and using the same
The present disclosure provides antibacterial prodrugs and methods of making and using the same.
Antimicrobial prochelators to target drug-resistant bacteria and methods of making and using the same
The present disclosure provides antibacterial prodrugs and methods of making and using the same.
Probes for rapid and specific detection of mycobacteria
The compositions of the present disclosure provide novel fluorogenic probes for use in the specific imaging and detection of mycobacteria species, and in particular -lactam-antibiotic resistant. Specificity for mycobacteria is conferred on these probes by incorporating a moiety that specifically targets the unique trapping mechanism of the DprE1 found in in mycobacteria. Accordingly, only Mycobacteria species that express both a -lactamase and DprE1 enable both the activation of the caged fluorescent probe, and the affixing of the released fluorescent probes to the bacteria cells through the functioning reduction-covalent binding mechanism. Advantageously, such a probe is able, at its most sensitive, to allow single mycobacterium detection.
2,7-disubstituted cephalosporin derivatives as β-lactamase substrates and methods for their use for the diagnosis of tuberculosis
-Lactamase substrates and methods for using the substrates to detect -lactamase and to diagnose tuberculosis.