Patent classifications
C
CHEMISTRY; METALLURGY
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C07
ORGANIC CHEMISTRY
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C07F
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
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9/00
Compounds containing elements of Groups 5 or 15 of the Periodic Table
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C07F9/38
Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids; ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
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C07F9/4003
the acid moiety containing a substituent or a structure which is considered as characteristic
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C07F9/4025
Esters of poly(thio)phosphonic acids
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C07F9/4028
containing no further substituents than -PO3H2 groups in free or esterified form
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C07F9/4031
Acyclic unsaturated derivatives
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C07F9/4031

ALKYLIDENE PHOSPHONATE ESTERS AS P-GLYCOPROTEIN INDUCERS
20170275314 · 2017-09-28 ·

The present invention relates to the alkylidene phosphonate esters of formula I wherein, R.sub.1 is selected from a group consisting of hydrogen or alkyl group; R.sub.2 is selected from a group consisting of hydrogen, hydroxy, alkyl, alkoxy, nitro, halogen, amino, N-substituted alkylamino; alkyl group is selected from a group consisting of methyl, ethyl and isopropyl; Ar is selected from a group consisting of aryl, substituted aryl, fused aryl, heteroaryl, and substituted heteroaryl. The present invention particularly relates to synthesis and p-glycoprotein induction activity of the alkylidene phosphonate esters. In addition, the invention relates to methods of using compounds for treating or preventing Alzheimer's disease.

##STR00001##

Alkylidene phosphonate esters as p-glycoprotein inducers
10377781 · 2019-08-13 · ·

The present invention relates to the alkylidene phosphonate esters of formula I wherein, R.sub.1 is selected from a group consisting of hydrogen or alkyl group; R.sub.2 is selected from a group consisting of hydrogen, hydroxy, alkyl, alkoxy, nitro, halogen, amino, N-substituted alkylamino; alkyl group is selected from a group consisting of methyl, ethyl and isopropyl; Ar is selected from a group consisting of aryl, substituted aryl, fused aryl, heteroaryl, and substituted heteroaryl. The present invention particularly relates to synthesis and p-glycoprotein induction activity of the alkylidene phosphonate esters. In addition, the invention relates to methods of using compounds for treating or preventing Alzheimer's disease. ##STR00001##