The present invention relates to compounds of formula (I), or the tautomers or pharmacologically acceptable acid addition salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X, and Z have one of the meanings as defined in the specification, to the use of compounds of formula (I) as a medicament, to pharmaceutical composition comprising at least one compound of formula (I), as well as to medicament combinations containing one or more compounds of formula (I).

##STR00001##

The present disclosure provides certain bicyclic heteroaryl compounds that inhibit ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) enzymatic activity and are therefore useful for the treatment of diseases and conditions modulated at least in part by ENPP1. In some embodiments, the bicyclic heteroaryl compounds includes those of Formula (I). Also provided herein are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

##STR00001##

A light-emitting device includes: a first electrode; a second electrode facing the first electrode; and an interlayer between the first electrode and the second electrode and comprising an emission layer, wherein the interlayer further includes an electron transport region between the emission layer and the second electrode, the electron transport region includes a first compound of Formula 1 and a second compound of Formula 2, the first compound and the second compound are different from each other, and the second compound includes at least one π electron-deficient nitrogen-containing C.sub.1-C.sub.60 cyclic group, where Formulae 1 and 2 are described herein.

The present invention provides compounds, compositions thereof, and methods of using the same.

The present invention relates to compounds comprising a benzimidazole scaffold, and the use of such compounds for the treatment of viral diseases. The invention also relates to pharmaceutical compositions comprising said compounds as an active ingredient. In particular the compounds of the invention comprising a benzimidazole scaffold are used for the treatment of filoviruses or retroviruses, and preferably for the treatment of Ebola virus or HIV virus.

The present invention provides compounds, compositions thereof, and methods of using the same.

The present invention provides compounds, compositions thereof, and methods of using the same.

The present invention relates to hydrosoluble compounds derived from benzimidazole represented by general formula I:

##STR00001##

wherein: Y.sup.1 e Y.sup.2 are independently O or S, and at least one of Y.sup.1 and Y.sup.2 is O; R.sup.1 and R.sup.2 are independently hydrogen or a cation, both are hydrogen or both are cations; R.sup.3 is a C1-4 alkyl; R.sup.4 and R.sup.5 are independently halogen or a —OR.sup.6 alkoxide; R.sup.6 is C6-C10 aryl linked in 5- or 6-position of benzimidazole nucleus.

Disclosed are a heterocyclic compound and an organic light emitting device including the same.

The present invention pertains to process for preparing nucleoside phosphoramidate and its intermediate. The present invention provides novel intermediate, its process for preparation and its use for the preparation of Sofosbuvir.