Patent classifications
C07H19/14
4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
The present invention is directed to 4′-substituted nucleoside derivatives of Formula I
##STR00001##
and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC.
4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
The present invention is directed to 4′-substituted nucleoside derivatives of Formula I
##STR00001##
and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC.
METHOD FOR TREATING POXVIRIDAE INFECTIONS
Disclosed herein are methods, compositions and kits for treating and inhibiting Poxviridae virus infections, for example, Vaccinia virus infections. Further disclosed are stop-gap methods for controlling the spread of Poxviridae virus infections.
MODIFIED NUCLEOTIDES AND USES THEREOF
Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.
MODIFIED NUCLEOTIDES AND USES THEREOF
Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.
NUCLEOTIDE ANALOGUES
Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
NUCLEOTIDE ANALOGUES
Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5)
The disclosure is directed to pharmaceutically acceptable salts of the compound of Formula I (I). Pharmaceutical compositions comprising pharmaceutically acceptable salts of the compound of Formula I, as well as methods of their use and preparation, are also described.
##STR00001##
Spirobicyclic analogues
The present invention relates to novel spirobicyclic analogues of Formula (I) ##STR00001##
wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS
Disclosed herein, inter alfa, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.