Modified exosomes are disclosed that include an exosome and a targeting modality that extends outwardly from a surface membrane of the exosome. Also disclosed are methods of producing and using the modified exosomes.

Modified exosomes are disclosed that include an exosome and a targeting modality that extends outwardly from a surface membrane of the exosome. Also disclosed are methods of producing and using the modified exosomes.

A method for obtaining a collagen peptide from a starfish, an elastic liposome containing a starfish-derived collagen peptide, and a cosmetic composition containing the same are disclosed. Methods of using the collagen peptide or the elastic liposome are disclosed. The collagen peptide obtained from a starfish has excellent skin absorption rate and having anti-oxidation and wrinkle-improving activity. Thus, the collagen peptide may replace existing animal collagen to provide collagen with high extraction efficiency.

A method for obtaining a collagen peptide from a starfish, an elastic liposome containing a starfish-derived collagen peptide, and a cosmetic composition containing the same are disclosed. Methods of using the collagen peptide or the elastic liposome are disclosed. The collagen peptide obtained from a starfish has excellent skin absorption rate and having anti-oxidation and wrinkle-improving activity. Thus, the collagen peptide may replace existing animal collagen to provide collagen with high extraction efficiency.

An object is to provide a peptide gelling agent which gels under physiological conditions and which has a relatively short chain length, and a sustained-release gel based on it. Provided is a hydrogelling self-assembling peptide comprising one or two core peptides consisting of an amino acid sequence represented by the following formula: Xaa-Yaa-Zaa-Yaa-Xaa-Yaa-Zaa-Yaa-Xaa, wherein Xaa is independently Ile or Met, Yaa is independently Asp, Glu, Lys, or Arg, and Zaa is independently Ala or Gly, and wherein the full length of the amino acid sequence constituting said self-assembling peptide is 25 amino acids or less.

The objective of the present invention is to provide an affinity separation matrix having excellent adsorption performance and binding capacity to a peptide containing a Fab region of IgG, and a method for producing a Fab region-containing peptide using the affinity separation matrix. The affinity separation matrix according to the present invention is characterized in that a Fab region-binding peptide is immobilized as a ligand on a water-insoluble carrier in a density of 1.0 mg/mL-gel or more.

A novel statherin-based fusion peptide is provided. The fusion peptide comprises the statherin peptide, DSSEEKFLR, or a functionally equivalent variant thereof, fused to an acquired enamel pellicle protein or peptide. The statherin-based fusion peptide is useful to treat dental demineralization. Also provided is hydrogel-encapsulated enamel-protective protein or peptides such as statherin, a statherin-based fusion peptide or a histatin.

A novel statherin-based fusion peptide is provided. The fusion peptide comprises the statherin peptide, DSSEEKFLR, or a functionally equivalent variant thereof, fused to an acquired enamel pellicle protein or peptide. The statherin-based fusion peptide is useful to treat dental demineralization. Also provided is hydrogel-encapsulated enamel-protective protein or peptides such as statherin, a statherin-based fusion peptide or a histatin.

A carrier system that includes a nanocarrier and a peptide non-covalently associated with the nanocarrier. The peptide contains an adaptor peptide sequence fused to the N-terminus of a target peptide, the adaptor peptide sequence being designed to facilitate the association to the nanocarrier. Also disclosed is a method for improving the immunogenicity of a peptide antigen by fusing it to an adaptor peptide sequence to form an immunizing peptide and contacting the immunizing peptide with a compatible nanocarrier. Further, a method is provided for treating a condition by immunization with a target peptide that has been fused to an adaptor peptide sequence and thereby associated with a nanocarrier. The method induces an immune response against the target peptide for treating cancer, viral infection, bacterial infection, parasitic infection, autoimmunity, or undesired immune responses to a biologies treatment.

A carrier system that includes a nanocarrier and a peptide non-covalently associated with the nanocarrier. The peptide contains an adaptor peptide sequence fused to the N-terminus of a target peptide, the adaptor peptide sequence being designed to facilitate the association to the nanocarrier. Also disclosed is a method for improving the immunogenicity of a peptide antigen by fusing it to an adaptor peptide sequence to form an immunizing peptide and contacting the immunizing peptide with a compatible nanocarrier. Further, a method is provided for treating a condition by immunization with a target peptide that has been fused to an adaptor peptide sequence and thereby associated with a nanocarrier. The method induces an immune response against the target peptide for treating cancer, viral infection, bacterial infection, parasitic infection, autoimmunity, or undesired immune responses to a biologies treatment.