An ionic diol has formula wherein R.sup.1 represents an alkyl group having from 6 to 18 carbon atoms; R.sup.2 and R.sup.3 independently represent alkyl groups having from 1 to 4 carbon atoms; R.sup.4 represents an alkylene group having from 2 to 8 carbon atoms; and R.sup.5 represents an alkylene group having from 1 to 8 carbon atoms. Antistatic polymers are formed by copolymerization of monomers including a diisocyanate, an ionic diol, a polyether diol, and at least one non-ionic diols. Methods of making the antistatic polyurethanes are also disclosed.

##STR00001##

The present invention relates to a composition for topically delivering SDF-1 into the brain, in which the composition comprises a dual ionic pH-sensitive copolymer and a nerve regeneration and protective factor. In the present invention, when a dual ionic pH-sensitive copolymer containing SDF-1 as a nerve regeneration and protective factor is applied to a patient suffering from ischemic stroke as a drug carrier, it induces the effective delivery of the treatment factor to a topical lesion site, and moreover, the risk factors for adverse effects may be cancelled out, so that it can be effectively used as a novel therapeutic agent for ischemic brain diseases.

Provided is a composition for forming polyurethane resin having a balance between reactivity and reducing viscosity and successfully imparting low-temperature storage stability, for use in fixing a hollow or flat sheet fiber separation membrane; and an MDI prepolymer containing a large amount of allophanate group without a metal compound and a method for producing the same while successfully controlling a reaction. Solution is provided by using a composition for forming polyurethane resin, containing a specific isocyanate group-containing compound; allophanatizing MDI with a tertiary amine catalyst without containing a metal catalyst; and reacting in the presence of at least one selected from the group consisting of a carboxylic acid amide, a sulfonic acid amide and an active methylene compound.

An m-phenylenediamine compound is represented by the following General Formula (I), (II), or (III). ##STR00001##
R.sup.1 represents a hydrogen atom, an alkyl group, a cycloalkyl group, or an aryl group. R.sup.2, R.sup.3, and R.sup.4 each represent an alkyl group. R.sup.5 and R.sup.6 each represent an alkyl group. X represents a chlorine atom or a bromine atom. A method for producing a polymer compound includes obtaining a polymer compound by using the m-phenylenediamine compound represented by General Formula (I) as a raw material.

The present invention relates to an aqueous polyurethane urea dispersion containing a polyurethane urea and a preparation process and use thereof, especially to the use in the field of coatings, adhesives or sealants, and the products obtained by coating, bonding or sealing with the polyurethane urea dispersion. The polyurethane urea of the aqueous polyurethane urea dispersion containing the polyurethane urea is obtained by the reaction of a system including the following components: a mixture of isocyanates, a polymer polyol, a monofunctional nonionic hydrophilic compound and a potentially anionic or anionic hydrophilic compound; said aqueous polyurethane urea dispersion has a viscosity of 5 s-18 s; relative to the total weight of said aqueous polyurethane urea dispersion, the amount of said polyurethane urea is 30 wt %-50 wt %. The aqueous polyurethane urea dispersion of the present invention has good compatibility with various organic solvents.

Provided is a composition for forming polyurethane resin having a balance between reactivity and reducing viscosity and successfully imparting low-temperature storage stability, for use in fixing a hollow or flat sheet fiber separation membrane; and an MDI prepolymer containing a large amount of allophanate group without a metal compound and a method for producing the same while successfully controlling a reaction.

Solution is provided by using a composition for forming polyurethane resin, containing a specific isocyanate group-containing compound; allophanatizing MDI with a tertiary amine catalyst without containing a metal catalyst; and reacting in the presence of at least one selected from the group consisting of a carboxylic acid amide, a sulfonic acid amide and an active methylene compound.

An m-phenylenediamine compound is represented by the following General Formula (I), (II), or (III).

##STR00001##

R.sup.1 represents a hydrogen atom, an alkyl group, a cycloalkyl group, or an aryl group. R.sup.2, R.sup.3, and R.sup.4 each represent an alkyl group. R.sup.5 and R.sup.6 each represent an alkyl group. X represents a chlorine atom or a bromine atom. A method for producing a polymer compound includes obtaining a polymer compound by using the m-phenylenediamine compound represented by General Formula (I) as a raw material.

An ionic diol has formula wherein R.sup.1 represents an alkyl group having from 6 to 18 carbon atoms; R.sup.2 and R.sup.3 independently represent alkyl groups having from 1 to 4 carbon atoms; R.sup.4 represents an alkylene group having from 2 to 8 carbon atoms; and R.sup.5 represents an alkylene group having from 1 to 8 carbon atoms. Antistatic polymers are formed by copolymerization of monomers including a diisocyanate, an ionic diol, a polyether diol, and at least one non-ionic diols. Methods of making the antistatic polyurethanes are also disclosed. ##STR00001##

The present invention relates to a composition for topically delivering SDF-1 into the brain, in which the composition comprises a dual ionic pH-sensitive copolymer and a nerve regeneration and protective factor. In the present invention, when a dual ionic pH-sensitive copolymer containing SDF-1 as a nerve regeneration and protective factor is applied to a patient suffering from ischemic stroke as a drug carrier, it induces the effective delivery of the treatment factor to a topical lesion site, and moreover, the risk factors for adverse effects may be cancelled out, so that it can be effectively used as a novel therapeutic agent for ischemic brain diseases.

The present invention is a bio-electrode composition includes, as the component (A), a resin which has a urethan bond in a main chain and at least one salt selected from the group consisting of salts of ammonium, sodium, potassium, and silver formed with sulfonamide in a side chain. This can provide: a bio-electrode composition capable of forming a living body contact layer for a bio-electrode that is excellent in electric conductivity and biocompatibility, light-weight, manufacturable at low cost, capable of preventing significant reduction in the electric conductivity even when wetted with water or dried, soft, and excellent in stretchability and strength; a bio-electrode including a living body contact layer formed of the bio-electrode composition; and a method for manufacturing the bio-electrode.