A method of producing a medical polyoxypropylene polymer and a polyoxypropylene/polyoxyethylene block copolymer including (A) adding to a polyoxypropylene polymer which is obtained by ring-opening polymerization of propylene oxide to a starting substance having an active hydrogen reacting with the propylene oxide and contains allyl ether as an impurity, a tertiary alkoxide of alkali metal in an excess amount based on a molar number of the active hydrogen of the starting substance and heat treating at 115° C. or less to isomerize the allyl ether to propenyl ether; and (B) adding a mineral acid to the product obtained in step (A) to adjust pH to 4 or less and treating at 70° C. or less to hydrolyze the propenyl ether. Also disclosed is a method of producing a medical polyoxypropylene/polyoxyethylene block copolymer which includes performing ring-opening polymerization of ethylene oxide to the polyoxypropylene polymer obtained above.

An object of the present invention is to provide an adhesive composition that causes less warpage when dissimilar materials are bonded together, and has excellent adhesive strength. The present invention relates to an adhesive composition comprising a component (A) that is a monofunctional epoxy resin, a component (B) that is a polyfunctional radically polymerizable compound, a component (C) that is a curing agent, and a component (D) that is a thermal radical initiator, the component (C) being one or more selected from the group consisting of a component (c-1) that is an epoxy adduct-type latent curing agent, a component (c-2) that is a hydrazide compound, a component (c-3) that is a cyclic amidine salt, and a component (c-4) that is a thermal cationic polymerization initiator.

A polyalkylene glycol derivative with a minimal impurity content is prepared simply by the steps of reacting a compound having formula (III-I) or (III-II) with an electrophile having formula (IV) in the presence of an optional basic compound, to form a reaction solution containing a compound having formula (V), and passing the reaction solution through a column of cation and anion exchange resins to remove water-soluble impurities, for thereby purifying the desired polyalkylene glycol derivative.
R.sup.1R.sup.2OR.sup.3O.sub.n-1R.sup.3O.sup.M.sup.+(III-I)
R.sup.1R.sup.2OR.sup.3O.sub.n-1R.sup.3OH(III-II)
R.sup.4R.sup.5X(IV)
R.sup.1R.sup.2OR.sup.3O.sub.nR.sup.5R.sup.4(V)

The present invention relates to a compound of formula (I): ##STR00001## in which: the R.sub.1 and R.sub.2 groups, which may be identical or different, are, independently of one another, a saturated or unsaturated, linear, branched or cyclic hydrocarbon group having from 1 to 15 carbon atoms, preferably from 1 to 10 carbon atoms; the R.sub.3 and R.sub.4 groups, which may be identical or different, are selected, independently of one another, from a hydrogen atom, a methyl group or an ethyl group; the R, R.sub.6 and R.sub.7 groups, which may be identical or different, are selected, independently of one another, from a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms; n is an integer of 0 to 20; and m is an integer of 1 to 6.

The present invention relates to a method for producing polyether carbonate polyols by attaching alkyloxides and carbon dioxide to H-functional starter compounds, characterized in that at least one alcohol containing at least two urethane groups is used as the H-functional starter compound. The invention further relates to polyether carbonate polyols containing a structural unit of the formula (IV), wherein: R.sup.1 denotes a linear or branched C.sub.2 to C.sub.24-alkylene, which optionally can be interrupted by heteroatoms of O, S or N and can be substituted, preferably by CH.sub.2CH.sub.2 or CH.sub.2CH(CH.sub.3); R.sup.2 denotes a linear or branched C.sub.2 to C.sub.24-alkylene, C.sub.3 to C.sub.24-cycloalkylene, C.sub.4 to C.sub.24-alkylene, C.sub.5 to C.sub.24-aralkylene, C.sub.2 to C.sub.24-alkenylene, C.sub.2 to C.sub.24-alkynylene, each of which can optionally be interrupted by heteroatoms such as O, S or N and/or can be substituted with alkyl, aryl and/or hydroxyl groups, preferably C.sub.2 to C.sub.24-alkyls; R.sup.3 denotes H, linear or branched C.sub.1 to C.sub.24-alkyl, C.sub.3 to C.sub.24-cycloalkyl, C.sub.4 to C.sub.24-aryl, C.sub.5 to C.sub.24-aralkyl, C.sub.2 to C.sub.24-alkenyl, C.sub.2 to C.sub.24-alkynyl, each of which can optionally be interrupted by heteroatoms such as O, S or N and/or can each be substituted with alkyl, aryl and/or hydroxyl groups, preferably H; R.sup.4 denotes H, a linear of branched C.sub.1 to C.sub.24-alkyl, C.sub.3 to C.sub.24-cycloalkyl, C.sub.4 to C.sub.24-aryl, C.sub.5 to C.sub.24-aralkyl, C.sub.2 to C24-alkenyl, C2 to C.sub.24-alkynyl, each of which can optionally be interrupted by heteroatoms such as O, S or N and/or can each be substituted with alkyl, aryl and/or hydroxyl groups, preferably H; R.sup.5 denotes a linear or branched C.sub.2 to C.sub.24-alkylene, which can optionally be interrupted by heteroatoms such as O, S or N and can be substituted, preferably by CH.sub.2CH.sub.2 or CH.sub.2CH(CH.sub.3); and wherein R1 to R5 can be identical or different to each other.

The present invention relates to a process for preparing polyether polyols by adding alkylene oxides onto H-functional starter compounds, characterized in that at least one alcohol containing at least two urethane groups is used as H-functional starter compound. The invention further provides the polyether polyols containing a structural unit of the formula (IV) where R.sup.1 is linear or branched C.sub.2 to C.sub.24-alkylene which may optionally be interrupted by heteroatoms such as O, S or N and may be substituted, preferably CH.sub.2CH.sub.2 or CH.sub.2CH(CH.sub.3), R.sup.2 is linear or branched C.sub.2 to C.sub.24-alkylene, C.sub.3 to C.sub.24-cycloalkylene, C.sub.4 to C.sub.24-arylene, C.sub.5 to C.sub.24-aralkylene, C.sub.2 to C.sub.24-alkenylene, C.sub.2 to C.sub.24-alkynylene, each of which may optionally by interrupted by heteroatoms such as O, S or N and/or may each be substituted by alkyl, aryl and/or hydroxyl, preferably C.sub.2 to CM alkylene, R.sup.3 is H, linear or branched C.sub.1 to C.sub.24-alkyl, C.sub.3 to C.sub.24-cycloalkyl, C.sub.4 to C.sub.24-aryl, C.sub.5 to C.sub.24-aralkyl, C.sub.2 to C.sub.24-alkenyl, C.sub.2 to C.sub.24-alkynyl, each of which may optionally be interrupted by heteroatoms such as O, S or N and/or each of which may be substituted by alkyl, aryl and/or hydroxyl, preferably H, R.sup.4, is H, linear or branched O to C.sub.24-alkyl, C.sub.24-cycloalkyl, C.sub.4 to C.sub.24-aryl, C.sub.5 to C.sub.24-aralkyl, C.sub.2 to C.sub.24-alkenyl, C.sub.2 to C.sub.24-alkynyl, each of which may be interrupted by heteroatoms such as O, S or N and/or each of which may be substituted by alkyl, aryl and/or hydroxyl, preferably H, IV is linear or branched C.sub.2 to C.sub.24-alkylene which may optionally be interrupted by heteroatoms such as O, S or N and may be substituted, preferably CH.sub.2CH.sub.2 or CH.sub.2CH(CH.sub.3), and where R.sup.1 to R.sup.5 may be identical or different from one another, and the polyether polyols obtainable by the process according to the invention.

A method for preparing a polyether polyol in a continuous reaction cycle is described. In the method, a low molecular-weight alcohol is polymerized with an alkylene oxide to obtain a low molecular-weight polymer. The low molecular-weight polymer is used as an initiator to react with the alkylene oxide and the low molecular-weight alcohol in the presence of a DMC catalyst and an acid promoter to obtain an intermediate-target polymer. A portion of the intermediate-target polymer is used for producing the target polymer, and the other portion is recycled for reproduction of the intermediate-target polymer. No initiator prepared with a base catalyst is used, and thus the loss of material and the discharge of residue and waste water are reduced. The DMC concentration is kept constant in the target polymer during the production such that the dewatering time and induction time are greatly reduced.

A method for producing a narrowly distributed and high-purity polyalkylene glycol derivative having an amino group at an end, a polymerization initiator for use in the method, and a precursor of the polymerization initiator are provided. The present invention provides: a method for producing a polyalkylene glycol derivative having an amino group at an end, using, as a polymerization initiator, a compound represented by the general formula (I); a compound represented by the following general formula (I); and a precursor thereof: ##STR00001## wherein R.sub.A.sup.1a and R.sub.A.sup.1b each independently represent a protective group of the amino group, or one of R.sub.A.sup.1a and R.sub.A.sup.1b represents H and the other represents a protective group of the amino group, or R.sub.A.sup.1a and R.sub.A.sup.1b bind to each other to represent a cyclic protective group forming a ring; R.sub.A.sup.2 represents a linear, branched, or cyclic hydrocarbon group having 1 to 6 carbon atoms; R.sub.A.sup.3 represents a single bond, or a linear, branched, or cyclic hydrocarbon group having 1 to 20 carbon atoms, and the hydrocarbon group may contain a heteroatom; the total number of carbon atoms (or the total number of carbon atoms and heteroatoms) of R.sub.A.sup.2 and R.sub.A.sup.3 is 4 or more; and M represents an alkali metal.

The present invention discloses a Y-type discrete polyethylene glycol derivative, which has the advantages of determined molecular weights and the number of chain segments, and can avoid the defect of heterogeneity of a PEG derivative. In addition, the Y-type discrete polyethylene glycol derivative of the present invention may increase the water solubility of the discrete polyethylene glycol, and solve the problem of insufficient water solubility of the discrete polyethylene glycol-modified insoluble drug caused by an increase of the loading capacity.

A polyalkylene glycol derivative with a minimal impurity content is prepared simply by the steps of reacting a compound having formula (III-I) or (III-II) with an electrophile having formula (IV) in the presence of an optional basic compound, to form a reaction solution containing a compound having formula (V), and passing the reaction solution through a column of cation and anion exchange resins to remove water-soluble impurities, for thereby purifying the desired polyalkylene glycol derivative.

R.sup.1R.sup.2OR.sup.3O.sub.n-1R.sup.3O.sup.M.sup.+(III-I)

R.sup.1R.sup.2OR.sup.3O.sub.n-1R.sup.3OH(III-II)

R.sup.4R.sup.5X(IV)

R.sup.1R.sup.2OR.sup.3O.sub.nR.sup.5R.sup.4(V)