The present invention relates to a catalyst for reductive amination-reaction, and uses thereof. The catalyst according to the present invention can show a high amine conversion rate because it can maintain catalytic activity even in the presence of moisture particularly while basically maintaining the balance of dehydrogenation and hydrogenation reactions. Accordingly, the catalyst can be usefully used for preparing a polyetheramine compound through a reductive amination-reaction not only in a continuous preparation process but also in a batch preparation process, irrespective of the existence of moisture.

Linear polyfunctional polyglycidyl amine oligomeric and/or polymeric structures exhibiting at least two primary amines are described, which provide crosslinking capabilities for latex paint compositions. These crosslinkers not only exhibit latent crosslinking properties but also improve scrub resistance when compared with existing latex formulations. Once the latex is coated onto a substrate, the volatile base evaporates and the groups react to form a crosslinked coating with improved scrub resistant properties.

The present invention is directed to a covalently crosslinked hydrogel comprising the strain-promoted reaction product of an 8-member cycloalkyne functionalized polyalkylene glycol and a multi-arm glycerol exytholate triazide and methods for making them. Because the precursor materials can be manipulated without causing crosslinking, provided the strain threshold is not reached, these hydrogels permit mechanical control over when (and where) cross linking occurs and are easier to use than prior strain-activated or temperature-activated systems. These novel hydrogels do not require a catalyst to cross link, thus avoiding the biocompatibility problems common to many catalysts. Nor is the crosslinking process affected by the presence of catalysts or other substances, which have interfered with crosslinking in known strain induced hydrogels. Because of their crosslinking reaction kinetics, these novel hydrogels can encapsulate and transport highly sensitive cells and other biological additives and have no known toxic byproducts.

The present invention is directed to a covalently crosslinked hydrogel comprising the strain-promoted reaction product of an 8-member cycloalkyne functionalized polyalkylene glycol and a multi-arm glycerol exytholate triazide and methods for making them. Because the precursor materials can be manipulated without causing crosslinking, provided the strain threshold is not reached, these hydrogels permit mechanical control over when (and where) cross linking occurs and are easier to use than prior strain-activated or temperature-activated systems. These novel hydrogels do not require a catalyst to cross link, thus avoiding the biocompatibility problems common to many catalysts. Nor is the crosslinking process affected by the presence of catalysts or other substances, which have interfered with crosslinking in known strain induced hydrogels. Because of their crosslinking reaction kinetics, these novel hydrogels can encapsulate and transport highly sensitive cells and other biological additives and have no known toxic byproducts.

A polymer-prostaglandin conjugate comprising: a polymer backbone comprising a plurality of moieties of formula (I): where: T represents a triazole moiety; Q is independently selected at each occurrence and may be present or absent and when present represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon; D is selected from prostaglandins; and L is a group of formula (II) wherein R.sup.5 is selected from hydrogen and C.sub.1 to C.sub.6 alkyl; (R) indicates the end of the group bonded to the R group; and (D) indicates the end of the group attached to the group D. ##STR00001##

Provided are a protein conjugate in which a physiologically active polypeptide is linked to a biocompatible material via a non-peptidyl polymer-coupled fatty acid derivative compound serving as a linker, exhibiting an increased duration of physiological activity compared to natural forms and a preparation method therefor. Since an increase in serum half-life of the physiologically active polypeptide of the protein conjugate, in which the biocompatible material, the non-peptidyl polymer-coupled fatty acid derivative compound, and the physiologically active polypeptide are linked, is proved, the protein conjugate may be widely used in the field of protein drugs.

Provided is a novel method for preparing a long-acting drug conjugate and a long-acting drug conjugate prepared using the method.

A perfluoropolyether-based rubber composition which gives cured objects excellent in terms of heat resistance, low-temperature resistance, organic-solvent resistance, and acid resistance, the rubber composition being characterized by comprising (a) a linear perfluoropolyether compound having a number-average molecular weight of 1,000-100,000 and including at least two azido groups in the molecule and a divalent perfluoroalkyl ether structure in the main chain and (b) a linear perfluoropolyether compound having at least three ethynyl groups in the molecule.

The present invention relates to a block copolymer, comprising a hydrophilic first block, a hydrophobic second block, and a functional group capable of specifically binding to thiol.

A fluorine-containing ether compound represented by Formula (1) is provided.

R.sup.1—O—R.sup.2—CH.sub.2—R.sup.3—CH.sub.2—R.sup.4—R.sup.5  (1)

(in the formula, R.sup.3 is a perfluoropolyether chain; R.sup.1 is an alkenyl group having 2 to 8 carbon atoms or an alkynyl group having 3 to 8 carbon atoms; R.sup.2 and R.sup.4 are each independently a divalent linking group having one or more hydroxyl groups; and —R.sup.5 is a group represented by Formula (2) shown below.)

—O—(CH.sub.2).sub.g—N—R.sup.6R.sup.7  (2)

(in the formula, g is an integer of 2 or 3; R.sup.6 and R.sup.7 are the same or different saturated aliphatic groups; and R.sup.6 and R.sup.7 may form a ring structure together with a nitrogen atom.)