This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

The present invention relates to an additive to prevent phase separation between a low profile additive and the other components of the molding composition, said other components comprising at least an unsaturated resin and an unsaturated monomer.

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

The present invention relates to an additive to prevent phase separation between a low profile additive and the other components of the molding composition, said other components comprising at least an unsaturated resin and an unsaturated monomer.

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

An adhesive composition contains a polyurethane-polyolefin complex composed of a polyurethane having a first functional group and a polyolefin having a second functional group that reacts with the first functional group. The polyurethane and the polyolefin is bound by a reaction between the first functional group and the second functional group.

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.