Provided are gelatin powders and gels derived from marine sources of collagen such as jellyfish. Also provided are methods for producing marine-derived gelatin powders. The marine-derived collagen source is hydrolyzed then dialyzed to at least partially demineralize the marine-derived collagen source.

Provided are gelatin powders and gels derived from marine sources of collagen such as jellyfish. Also provided are methods for producing marine-derived gelatin powders. The marine-derived collagen source is hydrolyzed then dialyzed to at least partially demineralize the marine-derived collagen source.

The present disclosure relates to thermoplastic collagen elastomer compositions comprising collagen, at least one reactive thermoplastic elastomer, and at least one softener, as well as composite materials made from these compositions. Methods of making and using the thermoplastic collagen elastomer composite materials to produce engineered leather are also disclosed.

A preparation method of a hydrogel of a mercapto-modified macromolecular compound includes the steps of combining the mercapto-modified macromolecular compound with an acrylated macromolecular compound and/or an acrylated micromolecular crosslinker. The mercapto-modified macromolecular compound can be crosslinked with the acrylated macromolecular compound and/or the acrylated micromolecular crosslinker under physiological conditions to form the hydrogel. Due to the rapid mercapto-vinyl crosslinking reaction, the formed hydrogel system can be quickly gelled in situ after being injected into the body. The hydrogel is thus suitable for use in the fields of biomedicine, medical cosmetic plastic surgery and cosmetics.

Disclosed is a method of crosslinking protein fibers, including wool fibers, by (i) providing a crosslinking agent including an oxidized sugar mixture having a plurality of different oxidized sugars of different molecular lengths and having at least two aldehyde groups (e.g., oxidized soy flour sugars); and (ii) infiltrating a plurality of non-crosslinked protein fibers with the crosslinking agent under conditions effective to cause protein molecules contained in the non-crosslinked protein fibers to become crosslinked. This method yields a population of crosslinked protein fibers, where the protein molecules of the non-crosslinked protein fibers include amine groups that react with the aldehyde groups of the oxidized sugars to achieve the crosslinking of the protein molecules to yield the crosslinked protein fibers.

Disclosed is a method of crosslinking protein fibers, including wool fibers, by (i) providing a crosslinking agent including an oxidized sugar mixture having a plurality of different oxidized sugars of different molecular lengths and having at least two aldehyde groups (e.g., oxidized soy flour sugars); and (ii) infiltrating a plurality of non-crosslinked protein fibers with the crosslinking agent under conditions effective to cause protein molecules contained in the non-crosslinked protein fibers to become crosslinked. This method yields a population of crosslinked protein fibers, where the protein molecules of the non-crosslinked protein fibers include amine groups that react with the aldehyde groups of the oxidized sugars to achieve the crosslinking of the protein molecules to yield the crosslinked protein fibers.

The present technique pertains to a method of preparation of a succinylated collagen-fibrinogen hydrogel and a succinylated collagen-fibrinogen hydrogel prepared thereby. The method of preparation of a succinylated collagen-fibrinogen hydrogel according to the present technique can produce a collagen-based bio-substance in a simple process, wherein collagen can be prevented from being entangled and an improvement can be brought about in hydrophilicity, cell growth rate, cell compatibility, and cell diffusion capability, whereby the collagen-based bio-substance exhibits excellent biocompatibility in vivo.

The present invention belongs to the technical field of medical biological materials, in particular to a green and broad-spectrum protein cross-linking method. In the method, a mixed solution containing protein and silver ions is irradiated by a visible light source with a compound wavelength to obtain cross-linked protein materials with uniform morphology. Compared with the traditional protein cross-linking method, the preparation method does not involve toxic chemical reagents and is environmentally friendly; the method can cross-link a variety of proteins in a broad spectrum; the preparation method can ensure the original activity of protein to the greatest extent; the preparation method also has the advantages of simple steps and easy operation; the cross-linked protein prepared by the method has good biological activity and antibacterial properties, and has great application prospect.

Provided are an injectable intraocular microgel and an injectable intraocular hydrogel that are safe to a human body and that can release a drug in the eye for a long period of time. This injectable intraocular microgel may have a form in which a drug is loaded on a hyaluronic acid microgel generated by causing hyaluronic acid copolymers to cross-link with each other through a w/o emulsion method.

Method of preparing a keratin-based biomaterial is provided. The method comprises a) reacting keratin with a polymer having at least one of an amine and carboxylic functional group in the presence of a carbodiimide cross-linking agent to form a cross-linked keratin-polymer material; and b) freeze drying the cross-linked keratin-polymer material to form the keratin-based bio-material. A keratin-based biomaterial thus prepared is also provided.