Provided is a defoamer for a fermenter. A defoamer for a fermenter according to an embodiment of the present invention includes: a body (100) having a first hollow (110) at a central portion thereof and having a disk shape; a support (200) having a second hollow (210) connected with the first hollow (110), and extending from an upper surface (120) and a lower surface (130) of the body (100); and a plurality of first vanes (310, 320, 330, 340, 350, 360, 370, and 380) mounted on the lower surface (130) of the body (100).

This cell production device comprises: a cell production plate that includes a fluid circuit in which a plurality of functional sites are integrated; and a closed type connector that connects the fluid circuit to an external space in a closed manner, wherein the fluid circuit comprises, as the plurality of functional sites, an injection and discharge unit that injects or discharges a fluid into or out of the fluid circuit via the closed type connector, a variable volume unit that stores a fluid that is extruded or withdrawn by the injected or discharged fluid, and a cell induction and culture unit that performs at least one of induction and culture of cells based on the injected fluid.

A Disposable Bioprocess System including a Single-Use-Bioreactor, a Single-Use-Pump and a single-use micro-organism retention filter. Combined most suitable for cultivation of suspended micro-organisms in a liquid media at high micro-organism concentration in a perfusion mode continuous process for expression of biological material. The inlet port of the liquid Single-Use-Pump connects via a valve to the broth reservoir of the Single-Use-Bioreactor through a liquid conveying port. The outlet port of the liquid pumping Single-Use-Pump connects via a valve to a micro-organism retention filter. And a method for operating said sterile Disposable Bioprocess System in perfusion mode for continuously processing.

The present invention relates to smart tank for a bio-pharma process line, a smart tank assembly, a method for assembling a smart tank and a system comprising multiple smart tanks. The smart tank comprises a top plate element, at least one sidewall element, and a bottom plate element, wherein the top plate element, the at least one sidewall element and the bottom plate element are arranged to form a reservoir for receiving at least one biochemical medium. The smart tank comprises further at least one channel, for guiding the at least one biochemical medium and/or an operating medium.

The present invention relates to a method of changing culture medium of a suspension culture, the suspension culture comprising cells suspended in the culture medium, the method comprising: (i) transferring a fraction of the suspension culture into a container, wherein the container comprises at least one opening at the bottom; (ii) allowing the cells comprised in the fraction of the suspension to settle at the at least one opening at the bottom of the container by gravitation, thereby forming a supernatant; (iii) dispensing the cells settled at the bottom of the container (back) into the suspension culture; (iv) discarding the supernatant.

The present invention relates to a bioreactor agitator. According to one embodiment of the present invention a drive coupling part is coupled to an impeller part through the drive coupling part, and the rotary shaft coupled to the impeller by means of magnetic force is provided to be adjustable in height by means of an up-and-down transfer part, such that the entire interior of the housing part can be effectively stirred.

The present invention relates to a bio-reaction stirrer using a magnetic force. According to an embodiment of the present invention, a driving coupling part is axially formed inside a housing part and a plurality of impellers are provided according to the height direction of the driving coupling part, and the respective impellers can be selectively driven as necessary, thereby efficiently stirring the entire inside of the housing part.

The changes to the abstract are shown below:

The present invention relates to a bio-reaction stirrer using a magnetic force. According to an embodiment of the present invention, a driving coupling part is axially formed inside a housing part and a plurality of impellers are provided according to the height direction of the driving coupling part, and the respective impellers can be selectively driven as necessary, thereby efficiently stirring the entire inside of the housing part.

The present invention relates to a bio-reaction stirrer using a magnetic force. According to an embodiment of the present invention, a driving coupling part is axially formed inside a housing part and a plurality of impellers are provided according to the height direction of the driving coupling part, and the respective impellers can be selectively driven as necessary, thereby efficiently stirring the entire inside of the housing part.

The changes to the abstract are shown below:

The present invention relates to a bio-reaction stirrer using a magnetic force. According to an embodiment of the present invention, a driving coupling part is axially formed inside a housing part and a plurality of impellers are provided according to the height direction of the driving coupling part, and the respective impellers can be selectively driven as necessary, thereby efficiently stirring the entire inside of the housing part.

A bioreactor for culturing of cells is described. Screens suitable as a cell growth scaffold may comprise crossed fibers. Screens may be contained loosely in a screen holder, which in turn may be contained inside a manifold assembly. A lower manifold, screen holder and upper manifold may have identical or similar interior open cross-sections. Flow of liquid medium can occur upwardly through the array of screens, then flowing over a weir in the presence of an air pocket, and into a moat and a pump. The screen holder may have slots whose exterior-facing ligaments are rounded, and may have grooves whose interior-facing edges are rounded. These components may be located inside an incubator suitable to maintain desired environmental conditions and cleanliness.

A bioreactor has a container, an end plate, an agitator, a drive unit, and at least one field device arranged in the interior, field device electronics, a data transmission unit arranged on the end plate, and a motor head piece coupled in terms of energy to the drive unit. At least one communication unit is coupled in terms of signaling to the motor head piece and includes an adapter piece, having adapter electronics which are electrically connected to the field device electronics of the field device, and a communicator piece. The adapter piece and the communicator piece are separate components which can be coupled to one another, wherein the motor head piece is a separate component which can be coupled to the communication units.