Provided is a defoamer for a fermenter. A defoamer for a fermenter according to an embodiment of the present invention includes: a body (100) having a first hollow (110) at a central portion thereof and having a disk shape; a support (200) having a second hollow (210) connected with the first hollow (110), and extending from an upper surface (120) and a lower surface (130) of the body (100); and a plurality of first vanes (310, 320, 330, 340, 350, 360, 370, and 380) mounted on the lower surface (130) of the body (100).

System for detecting at least one presence of foam of a medium in a bioreactor plant, wherein the system comprises: —a bioreactor plant having at least one disposable container for receiving the medium that may comprise the foam; and—at least two capacitive sensor units which are attached at at least two different situating positions of the bioreactor plant, wherein the capacitive sensor units each comprise at least one electrode system for capacitive measurement and are able to detect the presence of foam at the at least two situating positions on the basis of the capacitive measurement; and wherein the capacitive sensor units are designed to transmit captured data relating to the presence of foam to at least one monitoring unit for monitoring, open-loop and/or closed-loop control of foam formation in the bioreactor plant on the basis of said data.

A system and a method for monitoring and regulating the level of contents in a vessel is disclosed. In some embodiments, the system or the method use laser beams and photosensors to determine the level of the contents of the vessel.

A bioreactor vessel has an optical foam sensor (36) with a foam contact surface for contacting the foam to be detected. The foam contact surface is an inner side of a window (38) transparent to light from the visible and ultraviolet spectral range in an outer wall of the bioreactor vessel (10). An outer side of the window (38) is coupled to an illumination and detection unit (52) with at least one first light source (56) of visible light and at least one photodetector (58) to detect light from the first light source (56) that is reflected in the bioreactor vessel (10). The foam contact surface has a titanium dioxide coating (44) superhydrophilizable by photoactivation with ultraviolet light and the illumination and detection unit (52) has at least one second light source (66) of ultraviolet light.

The present invention provides improved bioprocessing systems and methods for cell culture using the improved bioreactors, e.g., batch-fed or perfusion bioreactor cell culture systems for production of monoclonal or bi-specific antibodies, which are modified to include one or more membrane gas transfer modules in place of a sparger- or microsparger-based aeration systems to better regulate the levels of critical gases in a bioreactor cell culture, e.g., the dissolved levels of O2 and CO2, even at high cell densities, without subjecting the cells to bubble-burst associated cell death.

A nozzle system for fluid deployment for treating a biological fluid within a bioreactor, having a bioreactor having an internal volume; an adjustable nozzle deployed within the internal volume; a reservoir capable of containing an agent; and a tubing connecting the reservoir and the adjustable nozzle, wherein the adjustable nozzle is capable of being adjusted to distribute a processing agent in a plurality of distribution streams.

A monitoring system for monitoring a process includes a housing with a viewing panel. The viewing panel includes a view port. An emitter generates light and illuminates an observation zone of the process. A detector is disposed within the housing and is configured to detect light entering the housing through the view port and create a plurality of images of the process in the observation zone. A thermal regulation system is configured to generate heat in the vicinity of the viewing panel of the housing so as to increase the temperature of at least the view port above ambient temperature.

A bioreactor configured to contain a volume of liquid is provided. The bioreactor includes a collapsible bag able to contain the volume of liquid, a support structure surrounding and containing the collapsible bag, a first sparger connected to the collapsible bag, the first sparger having a first aperture size, and a second sparger connected to the collapsible bag, the second sparger having a second aperture size that is different from the first aperture size.

Provided is a culture bag accommodating a culture fluid, the culture bag is capable of suppressing foaming in the culture fluid when oscillating the culture fluid to perform a culture, and performing a culture with high efficiency. The culture bag includes a culture space accommodating a culture fluid, the culture space being an endless space to allow the culture fluid to circulate therein, in which the culture bag has an inner surface that comes into contact with the culture fluid to be accommodated therein, the inner surface including, at least in part thereof, a first surface formed of a fine structure and a second surface formed of a structure different from that of the first structure.

A sterile foam breaking system, (14, 42, 52) includes a foam collector (20) having an opening (26), configured to be disposed in a source (12) which generates foam. The sterile foam breaking system (14, 42, 52) further includes a non-coated type suction unit (23) coupled to the foam collector (20). The non-contact type suction unit (23) is configured to transfer the foam via the opening (26) of the foam collector (20) and break a portion of the foam to generate a first quantity of liquid droplets. The sterile foam breaking system (14, 42, 52) additionally includes a foam breaking unit (28, 44, 54) coupled to the non-contact type suction unit (23). The foam breaking unit (28, 44, 54) is configured to receive remaining portion of the foam and the first quantity of liquid droplets and break the remaining portion of the foam to generate a second quantity of liquid droplets.