A sterile packaging unit includes a disposable bioprocessing component (20) and a packaging (30). The disposable bioprocessing component (20) has a component wall that encloses a processing space and on which is secured a sensor system (40) with at least one sensor head (T, P, I, L, D) and with attached sensor electronics (42) that include a memory unit (44). The packaging (30) hermetically encloses the disposable bioprocessing component (20) and has a flexible packaging wall. The disposable bioprocessing component (20) and the packaging (30). are sterilized by being jointly irradiated with ionizing radiation. The sensor electronics (42) are connected electrically to a contact unit (34) extending through the packaging wall.

A Disposable Bioprocess System including a Single-Use-Bioreactor, a Single-Use-Pump and a single-use micro-organism retention filter. Combined most suitable for cultivation of suspended micro-organisms in a liquid media at high micro-organism concentration in a perfusion mode continuous process for expression of biological material. The inlet port of the liquid Single-Use-Pump connects via a valve to the broth reservoir of the Single-Use-Bioreactor through a liquid conveying port. The outlet port of the liquid pumping Single-Use-Pump connects via a valve to a micro-organism retention filter. And a method for operating said sterile Disposable Bioprocess System in perfusion mode for continuously processing.

The invention discloses a first connection unit having a plurality of sensor surfaces and which is adapted to be asepetically connected to a second connection unit mounted e.g. on a flexible bioreactor bag.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. In examples, at least one controller may monitor and control one or more parameters associated with the single-use bioreactor A method to cultivate and propagate mammalian cells is also provided. The method may include cultivating under suitable conditions and in a suitable culture medium in a first single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a second single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a third single-use bioreactor, and cultivating the cells in the third bioreactor.

This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals, using Disposable Containers (DCs).

A microporous substrate for detection of surface bound target analyte molecules includes a microporous substrate material having opposed surfaces and tapered micropores extending through the substrate with the micropores having wider openings on one side of the substrate compared to the other side. The micropores have bound therein analyte specific receptors complementary to the target molecules. When a liquid sample containing the target analyte molecules with optical probes attached to the target molecules is flowed through the substrate, they bind to their complementary analyte specific receptors and emit light. This microporous substrate structure gives an increase in the collection efficiency of light emitted from optical probes when the light is detected by a light detector spaced from the side of the microporous substrate facing the larger micropores openings compared to a light collection efficiency of light emitted from the optical probes when the micropores are straight and not tapered.

The invention relates to a modular processing system for biopharmaceutical and/or chemical processes, comprising: at least one processing unit; at least one adapter plate, which can be directly or indirectly fluidically connected to the processing unit, wherein the adapter plate has at least one adapter channel, through which at least one fluid flow can flow to the processing unit, wherein the adapter plate also has at least one deflection element and/or a pump and/or at least one valve; and an external control device. The adapter plate is designed in such a way that the fluid flow to the processing unit can be at least partially deflected with the at least one deflection element in the adapter channel and/or the fluid flow, preferably its pressure, is controllable with the at least one valve and/or the pump in the adapter channel. A respective at least one sensor is embedded in the processing unit and/or in the adapter plate, in order to detect at least one property of the fluid flow in the processing unit or the adapter plate. The external control device can be coupled to the at least one sensor in such a way that measurement data of at least one sensor can be read out, and the fluid flow in the processing unit and or the adapter plate can be centrally controlled based on the read-out measurement data. The invention also relates to a method for centrally controlling a modular processing system for biopharmaceutical and/or chemical processes.

A method for separating a suspension includes dispensing a liquid suspension into a compartment of a first bag assembly. The first bag assembly is then rotated using a centrifuge so as to at least partially separate the suspension, the first bag assembly being disposed within a first insert that is housed within a first cavity of a rotor of the centrifuge, the first insert having an annular lip portion that freely projects out of the first cavity of the rotor by a distance of at least 1 cm.

A bioreactor has a container, an end plate, an agitator, a drive unit, and at least one field device arranged in the interior, field device electronics, a data transmission unit arranged on the end plate, and a motor head piece coupled in terms of energy to the drive unit. At least one communication unit is coupled in terms of signaling to the motor head piece and includes an adapter piece, having adapter electronics which are electrically connected to the field device electronics of the field device, and a communicator piece. The adapter piece and the communicator piece are separate components which can be coupled to one another, wherein the motor head piece is a separate component which can be coupled to the communication units.