A lung breathing chip and cell stretching culture platform and an operating method thereof are disclosed. The lung breathing chip and cell stretching culture platform controls the output of the motor by programming, stretches the micro-fluidic chip by the cam component, changes the size of the cam component and the frequency of the motor rotation to change the stretching frequency and the amount of stretching to simulate the breathing of the lungs in different states, uses liquid electrophoresis technology to arrange the cells in the biocompatible hydrogel and the hydrogel three-dimensionally to imitate the three-dimensional cell tissue, and injects drugs through the dynamic perfusion system to realize the drug testing platform that the cells of the chip bionic lung tissue are stretched.

A modular cell culture system includes a standalone cell culture subunit with an interior cavity to house a cell culture substrate in a cell culture space, a radial flow manifold below the cell culture space, a fluid inlet to supply fluid to a center of the manifold, and a fluid outlet to remove fluid from the cavity. The cavity is arranged for fluid to flow in from the fluid inlet, then through manifold, then through the cell culture space, and then out through the fluid outlet. The subunit further includes an alignment feature on at least one of a top and a bottom of the standalone cell culture subunit. The manifold can supply fluid at a uniform rate across a width of the cell culture space, and the alignment feature aligns with an alignment feature of another standalone cell culture subunit, such that multiple standalone cell culture subunits are stackable.

Disclosed herein are scalable, modular bioreactor systems for efficient preparation of cell-based tissues. Also disclosed herein are methods, compositions, and apparatuses for preparing scaffolds.

A skin sample culture apparatus which has a base frame, with a skin sample receiving surface upon which at least part of the skin sample may be placed and which extends across an area defined by the shape of the frame. A securing member which is releasably connectable to the base frame and a grip which holds the skin sample under tension. The apparatus may include a tensioner to hold the sample under tension and means for introducing a fluid to the upper or lower surface of the sample.

A culture apparatus includes: an inner case having an opening in a front surface and stainless-steel shelf rests on left and right side surfaces, the inner case configured to be sterilized with hydrogen peroxide or by dry heat sterilization; and a stainless-steel shelf plate placed on the shelf rests and slid in a front-back direction, the stainless-steel shelf plate configured to be sterilized with hydrogen peroxide or by dry heat sterilization. The shelf plate has a base surface on which a culture is placed, flanges respectively formed by being bent upward, at bent portions in end portions on left and right sides of the base surface, and sliding members respectively provided to outer surfaces of the flanges, at least on a front side in a direction of movement when the shelf plate is being inserted, the sliding members made of a material different from a material of the inner case.

The present invention relates to smart tank for a bio-pharma process line, a smart tank assembly, a method for assembling a smart tank and a system comprising multiple smart tanks. The smart tank comprises a top plate element, at least one sidewall element, and a bottom plate element, wherein the top plate element, the at least one sidewall element and the bottom plate element are arranged to form a reservoir for receiving at least one biochemical medium. The smart tank comprises further at least one channel, for guiding the at least one biochemical medium and/or an operating medium.

Cultivation systems including a cultivation substrate configured to promote seaweed holdfast formation and seaweed attachment are disclosed. The cultivation systems may include one or more of a nutrient phase, an adhesive, a bioactive agent, a liquid containing phase. The cultivation substrates may be patterned. The cultivation systems may specifically retain and viably maintain specific seaweed species such as dulse, kelp and nori.

This invention is a system for the production of biomass from photosynthesizing microorganisms that includes a photobioreactor comprising a transparent panel made from two transparent sheets with a separation between them, with top and bottom openings and with transparent, parallel subdivisions that form a panel of vertically arranged, transparent cells, where each transparent cell has a top opening and a bottom opening; a lower recirculation chamber in fluid contact with the bottom openings of the transparent panel; an upper recirculation chamber in fluid contact with the top openings of the transparent panel; a gas distribution tube externally arranged along the edge of said transparent panel; where said gas distribution tube comprises gas injectors arranged in fluid contact with the interior of a plurality of transparent cells; and a supporting structure that supports the transparent panel, the lower recirculation chamber, the upper recirculation chamber and the air distribution tube.

Cell culture apparatus is disclosed comprising: a cell culture container comprising a flexible tube; a support table; and a pair of opposed holders for holding opposed portions of the tube in a fluid tight manner such that fluid cannot pass through the respective portion inside the tube, the spacing between the said pair being adjustable to provide an adjustable sealed volume in the tube between the holder pair.

The present technology is generally related to storage structures for cell engineering systems. The storage structures allow for multiple automated cell engineering systems to be held via a single structure, and presented to a user when desired or needed for direct access to the cell engineering system, and then returned to a storage or working position. Many storage structures can be arranged together in a clinical or hospital setting, or other cell therapy engineering manufacturing environment.