An anti-cancer virus composition including an icosahedral-shaped plant virus or virus-like particle linked to a HER2 antigen is described. The anti-cancer virus composition can be used for methods of treating or decreasing the risk of developing a HER2-expressing cancer in a subject by administering to a subject in need thereof an effective amount of the anti-cancer virus composition.

A vaccine composition including a plant virus particle linked to an HER2 antigen is described. The vaccine composition can be used for methods of treating or preventing an HER2-expressing cancer in a subject by administering to a subject in need thereof an effective amount of the vaccine composition.

An anti-cancer virus composition including an icosahedral-shaped plant virus or virus-like particle linked to a HER2 antigen is described. The anti-cancer virus composition can be used for methods of treating or decreasing the risk of developing a HER2-expressing cancer in a subject by administering to a subject in need thereof an effective amount of the anti-cancer virus composition.

A vaccine composition including a plant virus particle linked to an HER2 antigen is described. The vaccine composition can be used for methods of treating or preventing an HER2-expressing cancer in a subject by administering to a subject in need thereof an effective amount of the vaccine composition.

A vaccine composition including a plant virus particle linked to an HER2 antigen is described. The vaccine composition can be used for methods of treating or preventing an HER2-expressing cancer in a subject by administering to a subject in need thereof an effective amount of the vaccine composition.

A vaccine composition including a plant virus particle linked to an HER2 antigen is described. The vaccine composition can be used for methods of treating or preventing an HER2-expressing cancer in a subject by administering to a subject in need thereof an effective amount of the vaccine composition.