The present invention provides exosomes isolated from an animal, wherein the animal (a) has overcome a disease caused by a pathogen, and (b) it is free from the pathogen that causes the diseases. The invention also provides process for obtaining these exosomes and the use thereof in therapy.

Methods for producing viruses from adherent cells are provided. The methods include releasing virus from adherent host cells grown in a bioreactor, and purifying released virus by ultrafiltration and/or diafiltration. The methods can be used to manufacture viruses, including for clinical use, at reduced cost relative to conventional virus manufacturing methods.

The present invention provides exosomes isolated from an animal, wherein the animal (a) has overcome a disease caused by a pathogen, and (b) it is free from the pathogen that causes the diseases. The invention also provides process for obtaining these exosomes and the use thereof in therapy.

The present invention provides methods of production of a purified enveloped virus antigen. In particular, it provides purified Ross River Virus (RRV) antigens, and vaccines comprising purified, inactivated Ross River Virus (RRV) antigen.

A process is provided for storing a lipid containing composition in a biodegradable material, the method comprising the steps: a) providing a biodegradable material, wherein the biodegradable material comprises or consists essentially of a processed starch; b) providing the lipid containing composition, wherein the lipid containing composition comprises lipid nanoparticles, preferably providing a liquid formulation comprising the lipid containing composition and a liquid carrier; c) absorbing said a lipid containing composition into the biodegradable material; and d) storing the lipid containing composition in the biodegradable material at a storage temperature from 80 C. to 80 C. for a period of at least one day. The invention further provides a product obtainable by the process of any one of the preceding claims, the product comprising said lipid containing composition comprising lipid nanoparticles, which are accommodated inside said biodegradable material.