Provided herein is a chimeric Potato virus X (PVX) filament conjugated to a therapeutic agent, a fusogenic peptide or a nucleolin-specific peptide ligand. In one aspect, they additionally comprise encapsulating a nucleic acid. Also provided are methods for use of the compositions diagnostically and therapeutically.

The present invention relates to kits comprising plus-sense single stranded RNA viral vectors, as well as mixtures of these vectors and uses thereof, and methods for producing in a plant, or plant tissue, or plant cell simultaneously two or more polypeptides using the kits and vectors.

The present invention provides plant virus vectors developed from the Foxtail mosaic virus (FoMV). The vectors include a nucleic acid sequence encoding an infectious Foxtail mosaic virus (FoMV) with a functional movement encoding sequence operably linked to one or more regulatory elements functional in a plant. The plant virus vectors may be used to infect monocot plants, such as maize and can be used for VIGS, gene editing, gene expression or other transgenic protocols.

The disclosure provides modified plant viruses designed for delivering a nucleotide of interest into mammalian cells. The modified plant viruses include a plant virus nucleotide sequence (e.g. fragment) that is capable of transfecting a mammalian cell when that mammalian cell expresses a receptor for the modified plant virus. Accordingly, the disclosure also provides receptors for the modified plant viruses as well as methods of using the receptor or the modified plant virus and receptor.