A method of forming a polymer matrix array includes treating a surface within a well of a well array with a surface compound including a surface reactive functional group and a radical-forming distal group; applying an aqueous solution including polymer precursors to the well of the well array; and activating the radical-forming distal group of the surface coupling compound with an initiator and atom transfer radical polymerization (ATRP) catalyst to initiate radical polymerization of the polymer precursors within the well of the well array to form the polymer matrix array.

A method of forming a polymer matrix array includes treating a surface within a well of a well array with a surface compound including a surface reactive functional group and a radical-forming distal group; applying an aqueous solution including polymer precursors to the well of the well array; and activating the radical-forming distal group of the surface coupling compound with an initiator and atom transfer radical polymerization (ATRP) catalyst to initiate radical polymerization of the polymer precursors within the well of the well array to form the polymer matrix array.

Provided herein are compositions, kits, and methods for nucleic acid barcoding. The barcode compositions provided herein can be used to linearly, combinatorially, or spatially barcode a plurality of targets in a sample. Also provided herein is a device for use in a barcoding method provided herein comprising a light source and a sample holder.

Provided herein are compositions, kits, and methods for nucleic acid barcoding. The barcode compositions provided herein can be used to linearly, combinatorially, or spatially barcode a plurality of targets in a sample. Also provided herein is a device for use in a barcoding method provided herein comprising a light source and a sample holder.

The present invention provides a method for the detection of viable microorganisms in urine using DNA-crosslinking agent to differentiate between dead and live microorganisms. The DNA-crosslinking agent can penetrate cells which have compromised cell membranes, such as dead cells. The method of the present application comprises amplifying DNA in the urine sample which is pre-treated with the DNA-crosslinking agent. In addition, the method includes the step of centrifugation to remove supernatant from the urine.

The present invention provides a method for the detection of viable microorganisms in urine using DNA-crosslinking agent to differentiate between dead and live microorganisms. The DNA-crosslinking agent can penetrate cells which have compromised cell membranes, such as dead cells. The method of the present application comprises amplifying DNA in the urine sample which is pre-treated with the DNA-crosslinking agent. In addition, the method includes the step of centrifugation to remove supernatant from the urine.

The scChIA-Drop method is a microfluidics-based dual-indexing strategy for single-cell and single-molecule chromatin interaction analysis.

The scChIA-Drop method is a microfluidics-based dual-indexing strategy for single-cell and single-molecule chromatin interaction analysis.

The invention provides a method of determining the epigenetic chromosome interactions which are relevant to a prognostic companion epigenetic test for cancer.

The invention provides a method of determining the epigenetic chromosome interactions which are relevant to a prognostic companion epigenetic test for cancer.