Disclosed is a biogel nanosensor for detection of an analyte that includes an acryloyl or methacryloyl modified hydrogel and nucleic acid amplification reagents in picoliter or nanoliter volume in the form of microarray. Also disclosed are methods of making the disclosed biogel nanosensor, and methods of using the biogel nanosensors.

Provided herein are devices, methods, and systems for polynucleotide synthesis comprising a thermocycler comprising a plurality of individual reaction chambers having a capability to control its own temperature setting. The devices, methods, and systems provided herein further comprise a detection module and a light source that are used to monitor the progress of the polynucleotide synthesis reaction in the individual reaction chambers and the quality and quantity of the synthesized polynucleotides.

Provided herein are devices, methods, and systems for polynucleotide synthesis comprising a thermocycler comprising a plurality of individual reaction chambers having a capability to control its own temperature setting. The devices, methods, and systems provided herein further comprise a detection module and a light source that are used to monitor the progress of the polynucleotide synthesis reaction in the individual reaction chambers and the quality and quantity of the synthesized polynucleotides.

The present disclosure relates to compositions and methods for generating capture probes on a substrate for identifying the location of analytes in a biological sample.

A fluid sensor for detecting a content change, in particular a liquid front, in a sensor portion of a fluid system, wherein the fluid sensor includes at least one sensor electrode, the sensor electrode having an electrode potential and a capacitive behavior, the sensor electrode thus being capable to store electrical energy in an electrical field formed by the sensor electrode when being charged, causing the electrode potential to change accordingly, a capacitance value of the sensor electrode varies when the content changes, the fluid sensor includes evaluation electronics, the evaluation electronics including a unidirectional electrical device (UED), and an AC source, the AC source is coupled via the UED to the sensor electrode to charge the sensor electrode, and the evaluation electronics include a discharge path coupled to the sensor electrode for discharging the sensor electrode.

Certain embodiments are directed to a low-cost battery-powered spectrophotometric system (BASS) coupled with a microfluidic chip for POC analysis, as well as methods of using the same.

Certain embodiments are directed to a low-cost battery-powered spectrophotometric system (BASS) coupled with a microfluidic chip for POC analysis, as well as methods of using the same.

The instant disclosure provides nucleic acid amplification systems and multi-reaction analysis systems useful in the efficient processing of samples, including clinical samples. Integrated systems that include nucleic acid amplification devices functionally combined with multi-reaction analysis systems are also included. Also provided are methods for monitoring multiple concurrent nucleic acid amplification reactions that include the use of devices and systems described herein.

Processes and devices are disclosed that detect RNA and DNA in a sample, including without limitation RNA from coronaviruses, with said processes generating a fluorescent signal if a segment of a specific RNA molecule is present in a sample.

A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.