C12Y207/11027

Increasing plant oil content by improving activity of acetyl-CoA carboxylase

The present invention provides a method and means to change fatty acid and ultimately triacylglycerol production in plants and algae. Methods of the invention comprise the step of altering the activity levels of the committed step for de novo fatty acid biosynthesis, acetyl-CoA carboxylases (ACCase). More specifically, methods of the invention directly enhance the activity of ACCase by overexpression of α-CT or a catalytic portion thereof.

INCREASING PLANT OIL CONTENT BY IMPROVING ACTIVITY OF ACETYL COA CARBOXYLASE
20230416760 · 2023-12-28 ·

The present invention provides a method and means to change fatty acid and ultimately triacylglycerol production in plants and algae. Methods of the invention comprise the step of altering the activity levels of the committed step for de novo fatty acid biosynthesis, acetyl-CoA carboxylases (ACCase). More specifically, methods of the invention directly enhance the activity of ACCase by overexpression of -CT or a catalytic portion thereof.

METHODS AND GENETICALLY MODIFIED CELLS FOR PRODUCTION OF FATTY ACID ESTERS

A recombinant cell for producing a fatty acid ester. The recombinant cell is genetically engineered to produce a reduction in free fatty acids compared to a cell that has not been similarly genetically engineered. Methods for producing fatty acid esters while decreasing free fatty acid production are also described.

INCREASING PLANT OIL CONTENT BY IMPROVING ACTIVITY OF ACETYL-COA CARBOXYLASE

The present invention provides a method and means to change fatty acid and ultimately triacylglycerol production in plants and algae. Methods of the invention comprise the step of altering the activity levels of the committed step for de novo fatty acid biosynthesis, acetyl-CoA carboxylases (ACCase). More specifically, methods of the invention directly enhance the activity of ACCase by overexpression of -CT or a catalytic portion thereof.

USP10 MODULATION OF AMPK AND MTOR

Materials and methods for modulating activity of kinases such as AMPK and mTOR via the deubiquitinase, USP10, are provided herein. Also provided are materials and methods for treating clinical conditions mediated at least in part by such kinases, including obesity, diabetes, metabolic syndrome, and some cancers.

A METHOD FOR PRODUCING RESVERATROL

Recombinant hosts and methods for producing resveratrol in recombinant hosts are disclosed herein.