A depolymerase may be capable of degrading extracellular polymeric substances of Klebsiella pneumoniae capsular type K47. The depolymerase can degrade extracellular polymeric substances of Klebsiella pneumoniae. Such a depolymerase may be a) an enzyme having a sequence as set forth in SEQ ID NO: 1, or having at least 80% homology thereto and having an activity of degrading extracellular polymeric substances from K47 capsular Klebsiella pneumoniae; and/or b) an enzyme having a sequence as set forth in SEQ ID NO: 2, or having at least 80% homology thereto and having an activity of degrading extracellular polymeric substances from K47 capsular Klebsiella pneumoniae

The present invention discloses a recombinant bacteriophage comprising a phage genome polynucleotide including a gene encoding a heterologous antigen protein(s) and a killing gene encoding a protein that is capable of killing a host bacterium. Such a recombinant bacteriophage is designed to prime a subject's immune response and to kill the bacterium that it infects such that the prime and kill bacteriophage provides two lines of protection against infectious disease.

The present invention discloses a recombinant bacteriophage comprising a phage genome polynucleotide including a gene encoding a heterologous antigen protein(s) and a killing gene encoding a protein that is capable of killing a host bacterium. Such a recombinant bacteriophage is designed to prime a subject's immune response and to kill the bacterium that it infects such that the prime and kill bacteriophage provides two lines of protection against infectious disease.

The present invention discloses a recombinant bacteriophage comprising a phage genome polynucleotide including a gene encoding a heterologous antigen protein(s) and a killing gene encoding a protein that is capable of killing a host bacterium. Such a recombinant bacteriophage is designed to prime a subject's immune response and to kill the bacterium that it infects such that the prime and kill bacteriophage provides two lines of protection against infectious disease.

A depolymerase may be capable of degrading extracellular polymeric substances of Klebsiella pneumoniae capsular type K47. The depolymerase can degrade extracellular polymeric substances of Klebsiella pneumoniae. Such a depolymerase may be a) an enzyme having a sequence as set forth in SEQ ID NO: 1, or having at least 80% homology thereto and having an activity of degrading extracellular polymeric substances from K47 capsular Klebsiella pneumoniae; and/or b) an enzyme having a sequence as set forth in SEQ ID NO: 2, or having at least 80% homology thereto and having an activity of degrading extracellular polymeric substances from K47 capsular Klebsiella pneumoniae.