A fluid handling device includes a first channel, a second channel, and a valve disposed at a connection part between the first channel and the second channel. The valve include a partition wall disposed between the first channel and the second channel, and a diaphragm disposed so as to face the partition wall, a portion of the first channel, and a portion of the second channel. The diaphragm is configured in such a way that when no pressure is applied to the diaphragm, a gap, which serves as a third channel that allows the first channel and the second channel to communicate with each other, is formed between the diaphragm and the partition wall. In plan view, the length of the diaphragm in the extending direction of the third channel is longer than the length of the diaphragm in the direction orthogonal to the extending direction.

A microfluidic device includes a silicon device and a metallic component. The silicon device and the metallic component are attached by preparing a surface of a silicon device to be solderable, preparing a corresponding surface of a metallic component to be solderable, and soldering the prepared surface of the silicon device to the corresponding prepared surface of the metallic component with a solder of a pre-defined composition and thickness to accommodate strain due to co-efficient of thermal expansion (CTE) mismatch between the silicon device and the metallic component.

A microfluidic chip orients and isolates components in a sample fluid mixture by two step focusing, where sheath fluids compress the sample fluid mixture in a sample input channel in one direction, such that the sample fluid mixture becomes a narrower stream bounded by the sheath fluids, and by having the sheath fluids compress the sample fluid mixture in a second direction further downstream, such that the components are compressed and oriented in a selected direction to pass through an interrogation chamber in single file formation for identification and separation by various methods. The isolation mechanism utilizes external, stacked piezoelectric actuator assemblies disposed on a microfluidic chip holder, or piezoelectric actuator assemblies on-chip, so that the actuator assemblies are triggered by an electronic signal to actuate jet chambers on either side of the sample input channel, to jet selected components in the sample input channel into one of the output channels.

Microfluidic pumps are provided that use electrowetting to manipulate the location of one or more droplets of a working fluid (e.g., water) in order to pump tears, blood, laboratory samples, carrier fluid, or some other payload fluid. The working fluid is separated from the payload fluid by one or more droplets of an isolating fluid that is immiscible with the working fluid. The working fluid is manipulated via electrowetting, by applying voltages to two or more electrodes, to repeatedly move back and forth. Forces, pressures, and/or fluid flows exerted by the working fluid are coupled to the payload fluid via the droplet(s) of isolation fluid and reed valves, diffuser nozzles, or other varieties of valve can act as flow-rectifying elements to convert the coupled forces into a net flow of the payload fluid through the pump.

A technique for separating components of a microfluid, comprises a self-intersecting micro or nano-fluidic channel defining a cyclic path for circulating the fluid over a receiving surface of a fluid component separating member; and equipment for applying coordinated pressure to the channel at a plurality of pressure control areas along the cyclic path to circulate the fluid over the receiving surface, applying a pressure to encourage a desired transmission through the separating member, and a circulating pressure to remove surface obstructions on the separating member. The equipment preferably defines a peristaltic pump. Turbulent microfluidic flow appears to be produced.

A micro channel structure includes a substrate, a supporting layer, a valve layer, a second insulation layer, a vibration layer and a bonding-pad layer. A flow channel is formed on the substrate. A conductive part and a movable part are formed on the supporting layer and the valve layer, respectively. A first chamber is formed at the interior of a base part and communicates to the hollow aperture. A supporting part is formed on the second insulation layer. A second chamber is formed at the interior of the supporting layer and communicates to the first chamber through the hollow aperture. A suspension part is formed on the vibration layer. By providing driving power sources having different phases to the bonding-pad layer, the suspension part moves upwardly and downwardly, and a relative displacement is generated between the movable part and the conductive part, to achieve fluid transportation.

A device for canceling acoustic noise generated includes, in one example, an inlet channel configured to be fluidly connected to an inlet port of a pump and an outlet channel configured to be fluidly connected to an outlet port of the pump. The device also includes an inlet resonator and an outlet resonator, both having open ends and closed ends. The open ends of the inlet and outlet resonators are fluidly connected to the inlet and outlet channels, respectively. When in operation, the inlet and outlet resonators can cancel noise generated by the operation of the pump.

The present invention provides a microfluidic pump-based infusion anomaly state detection and control system, comprising: a microfluidic pump chip configured to control the vibration of an actuating device to output a liquid; a pressure sensor located in a pipeline behind the outlet of the microfluidic pump chip and configured to sense the change of the pressure of the liquid output by the microfluidic pump chip to output an electric signal; a signal conditioning circuit configured to perform signal conditioning on the electric signal to obtain a conditioned electric signal; a signal acquisition circuit configured to convert the conditioned electric signal from an analog signal into a digital signal; a signal processing unit configured to determine the working state of the microfluidic pump chip and the working state of an infusion pipeline according to the digital signal, and to send a signal to an alarming unit when an anomaly is found; the alarming unit configured to alarm according to the signal; and a control drive unit configured to adjust the output state of the microfluidic pump chip according to the output of the signal processing unit. The present invention can precisely control a microfluidic pump chip and accurately detect the anomaly state of the microfluidic pump chip and alarm in time.

A micropump implantable in an eye is presented. In some aspects, the micropump includes a ferromagnetic member, a power source, and a motor coil magnetically coupled to the ferromagnetic member and electrically coupled to the power source to receive power from the power source. The motor coil is configured to generate a magnetic field in the ferromagnetic member when power is applied to the motor coil by the power source. In some embodiments, a hermetically sealed housing encloses the motor coil and the power source and partially encloses the ferromagnetic member. The micropump further includes a pump diaphragm and a compression chamber. The micropump further includes an armature configured to move in response to the magnetic field in the ferromagnetic member and a plunger configured to cause fluid to flow through the compression chamber from an inlet to an outlet.

What is suggested is a micromembrane pumping device for pumping a fluid, having: a pump chamber to which an inlet valve, an outlet valve, and a membrane device for varying a volume of the pump chamber are associated, wherein the membrane device has a plate-shaped actuator for deforming the membrane device; and influencing means for influencing the plate-shaped actuator and the volume of the pump chamber; wherein the membrane device has a plate-shaped membrane body limiting the pump chamber; wherein the plate-shaped actuator is arranged on a side of the plate-shaped membrane body facing away from the pump chamber; wherein the plate-shaped actuator is mounted to and electrically insulated from the plate-shaped membrane body by an electrically insulating glue layer; wherein at least one embedded portion of a support body at or in which a deformation sensor for detecting a deformation of the membrane device is arranged, is arranged within the glue layer to detect the volume of the pump chamber; wherein the influencing means, the plate-shaped actuator and the deformation sensor form a closed-loop control circuit for regulating a volume flow.