Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.

A lyophilization method for lyophilizing products inside one or more vials within a lyophilization chamber is disclosed which includes humidifying a charge gas to a predetermined relative humidity, cooling shelves in the lyophilization chamber to a predetermined temperature, pressurizing the chamber with the humidified charge gas to a pressurization threshold to thereby achieving a target relative humidity level within the lyophilization chamber, and suddenly releasing pressure within the lyophilization chamber until a depressurization threshold is reached in a short time interval up to about 4 seconds, during the depressurization, product inside one or more vials nucleate.

Lyophilization methods for preparing protein formulations for long-term storage at room temperature or improved stability at refrigeration storage are provided. Specifically, the present application provides lyophilization methods to obtain a target percentage of residual moisture of a lyophilized product, such as 3-5% residual moisture. The secondary drying of the lyophilization can be conducted under controlling rate of desorption under a temperature which is similar to the shelf temperature of the primary drying. Alternatively, the lyophilization can be conducted without a distinguished secondary drying step.

A material drying system provides for consistent and efficient drying of organic materials, such as cannabis. In certain embodiments, a partial vacuum drying system is used to dry the materials and includes a container, a heating system, a depressurization system, and a control system. Air in the container is heated to within a range of temperatures and a low vacuum is applied to assist with evaporation. In addition, the volume flow rate of air pulled out of the container is monitored and maintained at a predetermined rate, which pulls moisture away from the materials so as to prevent degradation of the materials during the drying process while also reducing drying time. A relatively high air volume flow rate is maintained at low pressure by adjusting the area of an opening in the chamber.

Lyophilization methods for preparing protein formulations for long-term storage at room temperature or improved stability at refrigeration storage are provided. Specifically, the present application provides lyophilization methods to obtain a target percentage of residual moisture of a lyophilized product, such as 3-5% residual moisture. The secondary drying of the lyophilization can be conducted under controlling rate of desorption under a temperature which is similar to the shelf temperature of the primary drying. Alternatively, the lyophilization can be conducted without a distinguished secondary drying step.

Provided is a loading tray assembly for housing a lyophilization container and a related system and method. The loading tray assembly includes a chassis including a contact void configured to facilitate direct contact between the attached lyophilization container and a lyophilizer shelf. The method includes securing a multi-part lyophilization container including a peelable seal on a lyophilization loading tray assembly, inputting a liquid into a non-breathable section of the lyophilization container, loading the tray assembly into a lyophilizer, freezing the liquid, applying heat energy and a vacuum, the vacuum causing an opening of the peelable seal and occluding the lyophilization container to isolate the frozen liquid.

The invention relates to a freeze-drying system for drying products containing liquid and to a method for operating a freeze-drying system, said freeze-drying system having a vacuum chamber, in which at least one holding device for holding the products containing liquid is inserted, a coolable condenser being provided, on which liquid drawn from the product in a drying phase can be condensed from a vapor phase. According to the invention, at least one sound generator is arranged on the holding device, by means of which sound generator sound can be applied to the product during the drying phase.

Devices, systems, and methods used to freeze dry a substance are disclosed. The devices and systems include a freeze dryer including a freeze-drying chamber, heating members, a refrigeration system, a vacuum pump, and a plurality of sensors disposed within the freeze-drying chamber. The freeze-drying methods include four main phases of freeze drying a substance: Phase 1 - Freezing; Phase 2 - Vacuum Freezing; Phase 3 - Sublimation; Phase 3A - Sublimation Verification and Phase 4 - Final Drying. Phase 3 can include cycling the heating members on and off between upper and lower humidity thresholds to increase the temperature of the freeze-drying chamber.

A material drying system, method, and control system therefor that provides for consistent and efficient drying of various materials is disclosed. In certain embodiments, a vacuum kiln can use various temperature measurements to reduce the chance of overheating the materials. In certain embodiments, a vacuum kiln (or a control system therefore) can use sensed information, such as the temperature differential across a platen assembly or the duty cycle of a vacuum pump, to determine when a large group of material has reached a substantially uniform dryness level. In certain embodiments, a vacuum kiln as disclosed herein can reduce checking, splitting, over-drying, and under-drying of material without requiring parameters from a user.

A transport device having a plate; a conveyor to transport articles; a pusher to push and move a row of articles on the conveyor onto the plate; and a stopper to prevent the articles from being moved by the conveyor and to define the start of a row of articles being moved onto the plate by the pusher. The conveyor causes the positions of rows of articles stopped by the stopper to move alternately so that the positions of rows of articles moved onto the plate are shifted alternately.