This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals, using Disposable Containers (DCs).

A method of testing the structural integrity of a rigid container comprises performing a sampling process on the rigid container comprising sampling a volume of sample gas from a sampling region associated with the rigid container, wherein the method further comprises performing a detection process comprising producing one or more laser beams for excitation of one or more materials that may be in the volume of sample gas, wherein the one or more materials are representative of a gas and/or vapour and/or a liquid leak from the rigid container and detecting light that has passed through the volume of sample gas, and determining the presence and/or absence and/or amount of said one or more materials in the volume of sample gas based on detected light.

Methods, apparatus, systems and articles of manufacture are disclosed for leak detection from a thief hatch. An example thief hatch includes a vent control stem coupled to first and second sealing plates, the first and second sealing plates to control fluid flow through the thief hatch based on translation of the vent control stem, and an indicator extending from the vent control stem to provide a visual indication of a condition of the fluid flow.

A method for in-line leak testing of blow moulded containers wherein a conveyor line is fed with a continuous stream of blow moulded containers from a blow moulding machine, at least one measuring head is temporarily connected to a first blow moulded container. The measuring head is moved in order to follow the movement of said first blow moulded container which is pressurized by a source of pressurized gas, the source of pressurized gas is disconnected, said at least one measuring head is used to measure the pressure decay therein. The pressure decay is compared with stored data for the pressure decay of acceptable containers and an accept or non-accept signal is generated which implies proceeding or disposal of said first blow moulded container. The measuring head is moved against the moving direction of the conveyor line to a subsequent blow moulded container, and the process is repeated.

A leak detection device operable to measure fluid leaks in an element to be tested that is positioned in a first enclosure. In one example, a measuring module is positioned in a second enclosure and connected to the first enclosure and the element to be tested by an aeraulic connection. At least one of the first enclosure and the measuring module are thermally insulated using an insulating material.

The disclosure relates to a sealing arrangement comprising a gasket arranged to seal a gap formed between a first element and a second element, wherein the gasket is arranged to be located in the gap and to be in contact with the first and the second elements, where the gasket comprises two elongated gasket members located on a distance from each other so as to form an intermediate gasket space confined by the gasket members and said first and second elements, and in that the sealing arrangement further comprises a pressure source adapted to apply a pressure on the intermediate gasket space, said pressure source preferably being configured to maintain a set pressure difference towards the surroundings. The disclosure further relates to a method, a system, a computer program product arranged to perform the method, a further sealing arrangement and a further method of monitoring sealing integrity of a pharmaceutical production space.

Device for testing sealing of at least a part of a double-door sealed transfer system between two closed volumes, the system including a first flange and a and a second flange capable of being rigidly connected to one another, and a first door and a second door normally sealing openings respectively defined by the first and the second flanges, the device including a casing including a cavity provided with an opening, mechanical connection to a flange so that the cavity is closed by the flange and the door and an inflatable joint which, in the inflated state, is in contact with the flange and ensures a sealing allowing to verify the sealing between the flange and the door.

The present invention relates to a system (20; 20′) for detecting leaks for a part having a permeable zone, said system comprising: a test chamber (22, 22′) configured to receive the part to be tested; a device (24) suitable for varying the pressure in the test chamber and/or in the part to be tested; a measuring device (26) for measuring a physical quantity representative of the leak level; characterised in that said system (20; 20′) comprises a main pipe (30) configured to cooperate with the permeable zone of said part, said main pipe (30) having one end (30a) which communicates with the permeable zone, while the other end (30b) of said pipe (30) opens outside the test chamber (22; 22′).

A leakage detector for a fuel vapor processing system having a canister. The leakage detector includes a sealing system and a control unit. The sealing system is connected to the canister and is configured to sealingly close an inspection area, which includes the canister. The control unit is implemented by at least one programmed processor. The control unit is configured to calculate an amount of fuel vapor in the canister. The control unit is also configured to select a leakage detection method from the group consisting of a positive pressure type and a negative pressure type. The selection is made based on the calculated amount of the fuel vapor in the canister. The control unit is further configured to perform the leakage detection method in response to temporal changes in an internal pressure of the inspection area closed by the sealing system.

A pressure sensor for an evaporated fuel leak detector includes a sensor unit, a case, and a sealing resin. The sensor unit has a pressure receiving portion, a plurality of conduction terminals, and a mold resin portion. The case has a fluid flow path and a housing recess. Each remaining inner wall surface of the housing recess except for an inner wall surface on the conduction terminal side is provided with an inclined surface and a vertical surface, in a cross section along an axial direction perpendicular to a pressure receiving surface of the sensor unit. The inclined surface is inclined inward as toward a pressure receiving side. The vertical surface extends from the end of the inclined surface on the pressure receiving side to define a filling gap in which the sealing resin is filled between the side surface of the mold resin portion and the vertical surface.