This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals, using Disposable Containers (DCs).

A boss structure sealing experiment device for an IV type hydrogen storage cylinder. The device includes a high-pressure chamber, a sealing leakage structure, a cylinder mouth valve, and a low-pressure chamber, where the high-pressure chamber, the sealing leakage structure, and the low-pressure chamber are tightly connected to one another through flange bolts, and the cylinder mouth valve is tightly connected to the high-pressure chamber through threads. Further disclosed is a sealing experiment system. The system includes a boss structure sealing experiment device, a high-pressure gas supply device, and a leaked gas detection device. The high-pressure gas supply device consists of a hydrogen source, a compressor, a buffer tank, a valve, and a pressure gauge; and the leaked gas detection device consists of a gas mixing chamber, a carrier gas, and a gas leakage detector. Further disclosed is a test method for a boss structure sealing experiment.

A leak detection device operable to measure fluid leaks in an element to be tested that is positioned in a first enclosure. In one example, a measuring module is positioned in a second enclosure and connected to the first enclosure and the element to be tested by an aeraulic connection. At least one of the first enclosure and the measuring module are thermally insulated using an insulating material.

A dispenser head (100) for dispensing a unit (C) of a pharmaceutical drug or a food supplement or food is provided, said dispenser head (100) comprising: a dosing duct (102) extending along a dosing axis (104) and connecting an inlet port (106) for receiving the unit (C) from a reservoir (11) with an outlet port (108) for dispensing the unit (C); a support section (130) for the unit (C), which extends from the exit port (108) parallel to the dosing axis (104); and a retention section (110), which extends from the support section (130).

A method for testing a test specimen for the presence of a leak using a film chamber for accommodating the test specimen, wherein the film chamber comprises walls enclosing a film chamber volume, which walls include at least one flexible wall area, comprising the steps of: placing the test specimen into the film chamber, and closing the film chamber, characterized in that complete closing of the film chamber is determined on the basis of the signal of a position measuring device which detects the relative position of the film chamber walls with respect to each other.

An apparatus for automatic leak detection, including a chamber to enclose a test specimen. A vacuum pump is in selectable fluid communication via an adiabatic noise cancellation valve with the chamber. A pressure transducer determines a pressure in the test specimen and transmits a pressure signal to a controller. The controller is to control the adiabatic noise cancellation valve to cause the vacuum pump to draw a vacuum from a space between the test specimen and the chamber thereby creating an adiabatic noise cancelling condition in which a temperature of the test specimen is stabilized. The controller is to control a flow of a test gas into the test specimen, and to determine a pressure decay rate from the pressure signal. The controller is to determine if the test specimen meets a leak test specification based on the pressure decay rate under the adiabatic noise cancelling condition.

A leak detection device operable to measure fluid leaks in an element to be tested that is positioned in a first enclosure. In one example, a measuring module is positioned in a second enclosure and connected to the first enclosure and the element to be tested by an aeraulic connection. At least one of the first enclosure and the measuring module are thermally insulated using an insulating material.

A leak detection apparatus includes a test chamber and a vacuum source connected to the test chamber via a pneumatic line. A first pressure transducer is in communication with the test chamber. A controller is configured to collect and analyze data generated by the first pressure transducer at a predetermined frequency throughout an entire test cycle. The controller is also configured to convert specified collected data to logarithmic scale to accumulate a first set of data and apply a linear regression to the first set of data and determine regression parameters.

This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals, using Disposable Containers (DCs).

The method for testing the integrity of a seal of a cavity in an engine includes providing a sealed test tank external to the cavity, the test tank having an internal volume that is particularly selected, as described herein. A pressure differential is generated between the test tank and the cavity, by creating an initial test pressure within the test tank that is different than an ambient pressure inside the cavity. Gas flow between the test tank and the cavity is then permitted, and a change in pressure within the test tank is measured, as is a test time required for the pressure inside the test tank to reach a reference pressure. The measured test time is compared with a predetermined reference time, and the integrity of the seal may be confirmed when the test time is greater than or equal to the reference time.