A flow regulation device for volatile and semi-volatile sampling onto adsorbent media is provided. The flow regulation device includes a housing having an inlet, an outlet, a secondary inlet that is open to the ambient, a real time flow meter, a controller in electronic communication with the flow meter, and a three-way valve. Gas is drawn through the adsorbent media, into the inlet, and then to the outlet by a vacuum source joined to the outlet. The controller is configured to: (1) actuate the three-way valve to put the vacuum source in-line with the inlet; (2) continuously monitor the flow of gas through the inlet and calculate the time necessary to sample a pre-set volume of gas; and (3) after the pre-set volume of gas passes through the inlet, actuate the three-way valve to put the vacuum source in-line with the secondary inlet.

A system for collecting and retaining a sample from exhaled breath of a subject for analysis can include a two part housing, a two part trap section, and optionally a boat fitment. Disclosed is a portable fluid sampling device comprising: a housing including a first portion removably attachable to a second portion, the first and second portions being configured to combine to form a chamber therein, the chamber being configured to at least temporarily contain or hold a biological sample therein, at least one of the first portion and the second portion including an inlet, the other of the first portion and the second portion including an outlet, wherein the device further comprises at least one of the following: a) one of the first portion and the second portion including an end having a projection, the other of the first portion and the second portion including an end having a groove, the groove being configured to receive at least a portion of the projection therein; or b) tamper evident means for indicating that the first portion of the housing has previously been separated from the second portion of the housing.

A portable handheld sampling device for collecting aerosol particles in a stream of exhaled breath provided with an inlet and an outlet, wherein the sampling device further comprises a housing and a collecting device holder removably arranged at least partially inside the housing, wherein the housing and the collecting device holder are arranged to guide the stream of exhaled breath through the device from the inlet to the outlet, wherein said collecting device holder comprises at least two cylindrical conduits arranged in parallel, each defining a flow path in fluid connection with the inlet, wherein a cylindrical collecting device is arranged in each conduit, the collecting device being adapted to collect the aerosol particles in the exhaled breath. A method for collecting aerosol particles in exhaled breath of a user using a portable handheld sampling device by means of a reopening breathing maneuver.

A bioaerosol detector is operated in accordance with one or more first inputs. Operating the bioaerosol detector includes filtering pathogens from the air, extracting genetic material from the filtered pathogens, and analyzing the extracted genetic material to identify the filtered pathogens. While operating the bioaerosol detector in accordance with the one or more first inputs, a change is identified in an operating condition for the bioaerosol detector. In response, the bioaerosol detector is operated in accordance with one or more second inputs. At least one input of the one or more second inputs is distinct from a respective input of the one or more first inputs.

A bioaerosol detector is operated in accordance with one or more first inputs. Operating the bioaerosol detector includes filtering pathogens from the air, extracting genetic material from the filtered pathogens, and analyzing the extracted genetic material to identify the filtered pathogens. While operating the bioaerosol detector in accordance with the one or more first inputs, a change is identified in an operating condition for the bioaerosol detector. In response, the bioaerosol detector is operated in accordance with one or more second inputs. At least one input of the one or more second inputs is distinct from a respective input of the one or more first inputs.

Methods, apparatuses, and systems associated with aerosol collection devices (such as, but not limited to, breath-aerosol collector devices, breathalyzers) are provided.

A diagnostic device is disclosed for characterisation of particles from a patient's airways, such as a lung, when ventilated by a ventilator, and/or for control thereof, comprising a particle detecting unit configured to be connected to a conduit for passing expiration fluid from said patient, for obtaining data related to particles being exhaled from said patient's airways.

The present invention relates to provide, among other things, the methods, devices, and systems that can simply and quickly collecting and analyzing a tiny amount of vapor condensates (e.g. exhaled breath condensate (EBC)).

An apparatus for detecting Covid-19 infection in a subject, the apparatus comprising (a) a sampling apparatus for collecting a breath sample from a subject (b) An analyzer, comprising an ion mobility spectrometer (IMS), for receiving the sample from the sampling apparatus and for determining the presence in the sample of Volatile Organic Compounds (VOCs) indicative of Covid-19, the VOCs comprising at least three compounds selected from the group consisting of C1-C3 alcohols, C2-C8 aldehydes, C3-C4 ketones and C4-C6 alkyl esters.

A hybrid gas sampling device can combine the functionality of both whole air and sorbent based samplers. The sampling device can be used for collecting light to very heavy organic compounds, for subsequent thermal desorption into a GC or GCMS for quantitative measurement. The sampling device isolates collected samples of gas phase matrices in a sample vessel, provided with sorbent elements from a removable sample extraction device. The sampling device is operated by drawing a vacuum on the chamber through the sample extraction device after sampling, and then completing the extraction of the heavier organic compounds using a static, diffusive extraction under vacuum to allow optimal deposition of the heavier compounds on the sorbent. The vacuum container is cooled to draw any excess water back into the container, thereby dehydrating attached sorbent element(s) in preparation for thermal desorption into a GC or GCMS, eliminating interferences in the MS analyzer.