A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.

Disclosed is an optical flow cell (100, 300) and a method (400) for bioprocessing applications. The optical flow cell (100, 300) comprises a fluid inlet (102, 302), a fluid outlet (104, 304), and a fluid flow channel (106, 306) provided between said fluid inlet (102, 302) and said fluid outlet (104, 304). The optical flow cell (100, 300) also comprises an output optical waveguide (108, 308) configured to emit light into said fluid flow channel (106, 306), and a collector optical waveguide (110, 310) configured to collect light from said fluid flow channel (106, 306). An optical pathlength adjuster (120, 320) for varying the optical pathlength (130, 330) between said output optical waveguide (108, 308) and said collector optical waveguide (110, 310) is also provided.

The invention is configured to include a spectroscopy cell 100 as a container including one or more spaces, each of which has a plate shape and contains a to-be-measured object that transmits or reflects a terahertz wave; and a holder 6 including one or more first holder through-holes 6b and 6c disposed at positions corresponding to the spaces of the spectroscopy cell 100, each of the spaces containing the to-be-measured object. A body portion 1 of the spectroscopy cell 100 is made of a resin material that transmits the terahertz wave, and the spectroscopy cell 100 is loaded into the holder 6 and is used. The holder 6 has a function of holding the spectroscopy cell 100, and a function of correcting one or more of a distortion, a twist, and a bending of the spectroscopy cell 100.

Disposable, pre-sterilized, and pre-calibrated, pre-validated sensor components are provided. The sensor components interact with a sensor system having disposable fluid conduit or bioreactor bag and a reusable sensor assembly. The components can include an optical bench or inset optical component or module designed to be integrated within the disposable fluid conduit or bioreactor bag, which provides an optical light path through the conduit or bag. The sensors systems are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the disposable fluid conduit or bag and on the reusable sensor assembly. Methods for calibrating the sensor and for determining a target property of an unknown fluid are also disclosed. The devices, systems and methods relating to the sensor are suitable for and can be outfitted for turbidity sensing.

A cell detector and a cell detection method detect cell proliferation. A cell detector includes a light emitter, a culture vessel that accommodates a culture medium containing a cell, a first slit member including a first slit and a first light shield, and at least one light receiver that receives light emitted from the light emitter and passing through the culture medium and the first slit in the first slit member in an order of the culture medium and the first slit. The first light shield in the first slit member blocks light emitted from the light emitter and scattered by the cell in the culture vessel when the cell is at a position overlapping the first slit.

Disposable, pre-sterilized, and pre-calibrated, pre-validated sensor components are provided. The sensor components interact with a sensor system having disposable fluid conduit or bioreactor bag and a reusable sensor assembly. The components can include an optical bench or inset optical component or module designed to be integrated within the disposable fluid conduit or bioreactor bag, which provides an optical light path through the conduit or bag. The sensors systems are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the disposable fluid conduit or bag and on the reusable sensor assembly. Methods for calibrating the sensor and for determining a target property of an unknown fluid are also disclosed. The devices, systems and methods relating to the sensor are suitable for and can be outfitted for turbidity sensing.

A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir, (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.

The system and cuvette insert is disclosed where the insert has a top surface that includes a first and second vertical channel opening. A first vertical channel extends downwardly from the first vertical channel opening and a second vertical channel extending from the second vertical channel opening. The insert also has a side wall into which the viewing chamber is formed. The viewing chamber has an upper viewing chamber wall and a lower viewing chamber wall. These walls define the viewing chamber and may be substantially parallel to the floor of the cuvette into which the insert is inserted. At the end of the viewing chamber is a reflecting wall. The viewing chamber has two ends, with one end in fluid connection with the first vertical channel and the other end in fluid connection with the second vertical channel. The fluid connection between the viewing chamber and the first vertical channel may also include a first lateral channel. Likewise the fluid connection between the viewing chamber and the second vertical channel may include a second lateral channel.

A measuring vessel in which a gas to be analyzed by spectrometry is intended to flow, the vessel being in the form of a hollow tube provided with a reflective material forming an optical-reflection layer, including a hollow tube is produced from a non-metallic material, and a removable supple optical article is applied against the internal surface of the hollow tube, the article including a supple flexible support, one face of the support being covered with a reflective metal material, the article being inserted in the tube so that the reflective metal material forms the optical-reflection layer.

A capillary cell is described along with an arrangement and a method for receiving, positioning and examining a microscopic specimen, in particular a cleared fluorescent specimen with the help of a single-plane fluorescence microscope. The capillary cell is suitable for being positioned in a chamber volume and contains a capillary section, which comprises a wall. The wall encloses a specimen volume and is planar and transparent in at least some sections. In addition, the capillary cell includes an upper and a lower closure section, which are connected to the capillary section and which seal the capillary section. The specimen volume is separated from the chamber volume by the capillary section, the upper closure section and the lower closure section.