Provided are a bubble eliminating structure and a bubble eliminating method which eliminate bubbles in a liquid by agitating the liquid, and an agitating method using the same. A first groove 114, which is an upstream bubble eliminating groove, and a second groove 131, which is a downstream bubble eliminating groove, are branched from a mixing well 13. After starting suction of the liquid from mixing well 13 into the first groove 114, suction of the liquid from the mixing well 13 into the second groove 131 is started, and after completion of discharge of the liquid from the first groove 114 into the mixing well 13, discharge of the liquid from the second groove 131 into the mixing well 13 is completed. This operation is repeated to eliminate bubbles.

Technology is provided for a fluid transmissometer manifold. The transmissometer manifold includes a manifold body having an upwardly extending bubble diverter passageway with an upper end portion and a lower end portion. A flow restrictor is connected to the upper end portion and an inlet passageway is connected to the diverter passageway between the flow restrictor and the lower end portion. An upwardly extending optical chamber is connected to the lower end portion. At least a portion of a fluid entering the inlet passageway flows downward into the optical chamber and any bubbles contained in the fluid travel upward through the bubble diverter passageway. A light source can be positioned at a first end of the optical chamber and a detector positioned at a second end of the optical chamber opposite the light source and operative to detect light emitted from the light source.

Microfluidic cuvettes and a network of multiplexed channels including such cuvettes. The channels operationally share a main output channel defining an output of the network. A microfluidic channel includes an inlet, a cuvette, and an outlet that is coupled into the main output channel. The network is configured to provide a difference in resistances, to the fluid, by the main output channel and by an individual outlet is sufficient to prevent cross-contamination of different cuvettes, thereby operably isolating individual channels from one another. An individual cuvette is adapted to substantially prevent the formation of air-bubbles as part of the fluid flow through the cuvette and, therefore, to be fully filled and fully emptied. A system and method for photometric measurements of multiple fluid samples employing such network of channels.

A microfluidic device including a substrate having at least one droplet holder formed thereon, and a cover member facing the substrate with a space between the cover member and the substrate, and having a flow path formed in the space and connected to the droplet holder. The flow path has a height of more than 0 μm and 30 μm or less.

An optical milk measuring arrangement operative during a milking operation, and including an optical measuring device for measuring optical properties of milk in a measuring region, in which at least part of the milk fed to the measuring arrangement collects. The measuring arrangement includes a main channel and a measuring channel, and these channels are in fluid communication with one another in a region of a common inlet and a common outlet, and the measuring channel has a lower flow velocity than a flow velocity in the main channel.

A digital PCR measuring apparatus capable of measuring a melting curve with high accuracy is provided. The digital PCR measuring apparatus includes a temperature adjuster that controls a temperature of a sample container including a plurality of minute regions, a fluorescence measurement part that measures fluorescence intensity of a plurality of minute regions, and a controller that controls the temperature adjuster and the fluorescence measurement part. The controller controls the temperature adjuster to raise a temperature of the sample container, and, after removing air bubbles generated in the sample container, measures fluorescence intensity of a plurality of minute regions while controlling the temperature adjuster to lower the temperature of the sample container, and measures a melting curve of a plurality of the minute regions.

Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.

Reusable network of spatially-multiplexed microfluidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid. System and method for photometric measurements of multiple fluid samples employing such network of channels.

A probe-type online biomass detection apparatus capable of being subjected to high-temperature sterilization includes an optical fiber probe (1), a light source and light receiving sensor module (2), and a signal processing module (3). A portion, which is required to touch cytosol, of the apparatus adopts a detachable design scheme, to meet requirements for high-temperature sterilization of the probe (1). In the meantime, with regard to influence of bubbles in a fermentation tank on measurement values, a bubble filtering structure is provided, to reduce flow rate and number of the bubbles in the measurement area; and a measurement signal is filtered and optimized through a software algorithm, so that interference of the bubbles is eliminated finally.

A process tube device can detect the presence of any external materials that may reside within a fluid flowing in the tube. The process tube device detects the external materials in-situ which obviates the need for a separate inspection device to inspect the surface of a wafer after applying fluid on the surface of the wafer. The process tube device utilizes at least two methods of detecting the presence of external materials. The first is the direct measurement method in which a light detecting sensor is used. The second is the indirect measurement method in which a sensor utilizing the principles of Doppler shift is used. Here, contrary to the first method that at least partially used reflected or refracted light, the second method uses a Doppler shift sensor to detect the presence of the external material by measuring the velocity of the fluid flowing in the tube.