A method and system for the suppression and/or modulation of absorption spectrum artifacts for the purpose of gas detection and concentration measurements using at least one magnetic, electric or electromagnetic field. A field applied selectively to at least one section of the system modulates absorption by influencing quantum energy state transitions of gas species.

An apparatus for label-free analysis of molecules, including interactions and reactions of the molecules, is disclosed. The apparatus is based on detecting molecule movement under the influence of an external electric field. The apparatus is able to achieve sensitive detection of molecular binding to proteins or other molecules, and conformational changes of proteins or other molecules and biochemical reactions of the proteins or other molecules. Applications of the apparatus include screening of drug molecules, kinetic analysis of posttranslational modification of proteins, and small molecule-protein interactions.

An electrical polarity adjustable biosensor based on lossy mode resonance includes a first polarity module, a second polarity module, and a plurality of spacers disposed between the first polarity module and the second polarity module. A biomaterial sensing region for injecting an object to be tested is formed between a bioprobe layer of the first polarity module and a second electrode layer of the second polarity module. An electric field is formed between a lossy mode resonance layer of the first polarity module and the second electrode layer, and the electric field acts on a plurality of bioprobes of the bioprobe layer and the object to be tested. The present disclosure further includes a method of using the electrical polarity adjustable biosensor based on lossy mode resonance.

Methods and systems for performing optical measurements of semiconductor structures while modulating both an electric field within one or more structures under measurement and the measurement light employed to measure the one or more structures are presented herein. Spectroscopic ellipsometry, spectroscopic reflectometry, and angle resolved spectroscopic reflectometry measurements are enhanced by modulation of the electric field of the structures under measurement. The modulation of the electric field changes the dielectric function of the materials under measurement. Measurements are performed with an enriched data set including measurement signals collected from one or more structures under time varying optical and electric field conditions. This reduces parameter correlation among floating measurement parameters and improves measurement accuracy. Differences between frequencies of optical modulation and electric field modulation increase the contrast within the one or more structures under measurement, which, in turn, increases measurement accuracy with reduced computational effort.

The present disclosure provides apparatuses and methods for analyzing the presence of a target analyte. The apparatuses and methods of the present disclosure can be operated in a multiplexed format to perform various assays of clinical significance.

A detection substrate includes a substrate, a wetting layer, a barrier layer, a reaction layer, a counter electrode layer, a reference electrode layer, an insulating frame, and a plurality of wirings. The substrate includes a counter electrode, a working electrode, and a reference electrode. The reaction layer is located on the barrier layer. A surface of the reaction layer has a naturally micro-etched nano pattern. The counter electrode layer has an accommodating area which accommodates the reaction layer, and the naturally micro-etched nano pattern is exposed from the accommodating area. The insulating frame is located on a measurement area. The detection substrate has electrodes. During use, a predetermined reaction potential is applied to the detection substrate by an electrochemical device, and a Raman spectroscopy analysis is performed to obtain a strengthened Raman spectroscopy signal. A Raman spectrum detection system and a Raman spectrum detection method are also provided.

An optical inspection apparatus includes a stage that supports a target substrate, the target substrate including a plurality of light emitting elements, a jig that applies an electrical signal to the target substrate, the jig including a regulation resistor, a microscope that generates magnified image data of the target substrate, a camera that captures the magnified image data to generate a color image of the target substrate, and an optical measurement unit that captures the magnified image data of the target substrate to generate a spectrum image and measure optical characteristics of the target substrate.

An apparatus for analyzing a material includes an excitation emission device for generating at least one electromagnetic excitation beam, in particular an exciting light beam, having at least one excitation wavelength, further comprising a detection device for detecting a reaction signal, and a device for analyzing the material on the basis of the detected reaction signal.

The disclosed apparatus, systems and methods relate to ATPA technology that provides a method for the real-time assessment of the polymerization of a sample, e.g., whole blood or blood plasma coagulation, by a non-contact acoustic tweezing device. The acoustic tweezing technology integrates photo-optical tests used in plasma coagulation assays with mechanical (viscoelastic) tests used in whole blood analysis. Its key disruptive features are the increased reliability and accuracy due to non-contact measurement, low sample volume requirement, relatively short procedure time (less than 10 minutes), and the ability to assess the level of Factor XIII function from measurements of the fibrin network formation time.

The invention relates, inter alia, to a device (10) for analysing a material (101), comprising an excitation emission device (100) for generating at least one electromagnetic excitation beam (SA), particularly an excitation light beam, with at least one excitation wavelength, and further comprising a detection device (106) for detecting a reaction signal (SR), and a device (107) for analysing the material on the basis of the detected reaction signal (SR).