G01N2021/317

Optical coherence tomography apparatus and image generation method using the same

An optical coherence tomography (OCT) apparatus includes a light source unit to generate light, a coupler unit to generate coupled light using reference light and measurement light generated by splitting the light, split the coupled light into n coupled and split lights and irradiate the n coupled and split lights, wherein n is a natural number greater than or equal to 2, a detection unit to irradiate the incident n coupled and split lights to n spectroscopes respectively and sequentially scan each light separated from each of the spectroscopes by wavelength range, and an image generation unit to generate a 2-dimensional single image using a result of the scanning by the detection unit. Accordingly, it is possible to improve the OCT image acquisition rate by distributing the scan time for a plurality of split lights using a plurality of array detectors.

Systems and methods for skewed basis set fitting

Systems and methods for skewed basis set fitting may include obtaining measured absorption data indicative of an amount of absorption of light by a sample gas at each of multiple frequencies, determining an absorption dependent cavity time constant indicative of a skew to the measured absorption data caused by light reflections within a cavity in which the sample gas is contained, obtaining reference absorption data including basis sets indicative of reference amounts of light absorbed by each of multiple gases at each of the multiple frequencies, skewing the reference absorption data based on the absorption dependent cavity time constant to generate skewed reference absorption data, and fitting the measured absorption data to the skewed reference absorption data to identify an amount of at least one constituent gas within the sample gas.

Medical hyperspectral imaging for evaluation of tissue and tumor

Apparatus and methods for hyperspectral imaging analysis that assists in real and near-real time assessment of biological tissue condition, viability, and type, and monitoring the above overtime. Embodiments of the invention are particularly useful in surgery, clinical procedures, tissue assessment, diagnostic procedures, health monitoring, and medical evaluations, especially in the detection and treatment of cancer.

Compact spectrometer devices, methods, and applications

Methods, devices and systems provide improved spectral imaging and detection and can be implemented as compact, light-weight and low-cost devices. An example device includes a mask that includes a plurality of apertures and positioned to receive light from an object of interest. A first lenslet array is positioned to receive light that passes through the plurality of apertures. Each lenslet of the first lenslet array receives the light from a corresponding aperture and produces collimated light that is incident on a dispersive element, such as a diffraction grating or a prism, which produces a plurality of spectrally separated components. A second lenslet array receives the spectrally separated components and focuses each of the spectrally separated components onto an image plane, where a sensor is located. The information obtained from the sensor can be used to determine or analyze spectral characteristics of the object, which can be in gaseous form.

LIGHT RECYCLING ARTICLE FOR BIO-ASSAY

An optical well is configured to receive a test sample for examining an optical characteristic of the sample at a first wavelength in a predetermined wavelength range. The optical well includes a wall having a bottom wall portion and a sidewall portion defining a chamber for receiving the test sample, and an optical film formed into a shape so that a portion of the sidewall portion includes a first portion of the optical film, and a portion of the bottom wall portion includes a second portion of the optical film. For a normally incident light, the microlayers in each of the first and second portions have an average optical reflectance of greater than about 80% in the predetermined wavelength range. The forming results in the plurality of microlayers of the integral formed optical film having a thinnest portion and a thickest portion having a thickness difference of at least 30%.

SYSTEMS AND METHODS FOR DETECTING FOODBORNE PATHOGENS USING SPECTRAL ANALYSIS

An example system includes a light intensity measuring apparatus couplable to a food processing apparatus and a computing system. The light intensity measuring apparatus includes a chamber configured to receive a water sample from the food processing apparatus, a light source, a detector configured to detect light that has passed through the water sample and measure multiple times intensities of wavelengths of the light to obtain multiple sets of measured intensities of wavelengths, and a communication module configured to provide the multiple sets of measured intensities of wavelengths. The computing system may receive the multiple sets of measured intensities, process the multiple sets to obtain a set of values, apply a first set of decision trees to the set of values to obtain a first result indicating a positive or negative foodborne pathogen detection, generate a notification indicating either the positive of negative detection, and provide the notification.

Time-resolved hyper-spectral single-pixel imaging

A time-resolved hyper-spectral imaging system for imaging a sample, includes a radiation source suitable for illuminating the sample repeatably, a first optical system configured to form an image I of the sample on a spatial light modulator forming a transmission or reflection mask P, a processor connected to the spatial light modulator and configured to make the transmission or reflection mask P vary for each repetition of the illumination, a second optical system suitable for focusing the radiation transmitted or reflected by the spatial light modulator so as to form, in its image focal plane, a partial image S=P.Math.I; the imaging system being wherein it comprises: a dispersive device comprising a slit placed in the image focal plane of the second optical system, the dispersive device being suitable for spatially splitting the various wavelengths of the radiation transmitted or reflected by the spatial light modulator; a streak camera arranged so as to be illuminated by the radiation issuing from the dispersive device and configured to acquire a plurality of time-resolved partial images of the sample, the images being associated with respective and different transmission or reflection masks P, the streak camera being connected to the processor and the processor also being configured to combine the partial images of the sample so as to construct a 4D image cube I.sub.tot forming an image resolved in time and in wavelength of the sample; and corresponding time-resolved hyper-spectral imaging method for imaging a sample.

GAS SENSORS

A gas sensor for measuring concentration of a predetermined gas includes a light source (2) arranged to emit pulses of light, a measurement volume (10), a detector (4) arranged to receive light that has passed through the measurement volume (10), and an adaptable filter (6) disposed between the light source (2) and the detector (4). The gas sensor has a measurement state in which it passes at least one wavelength band which is absorbed by the gas and a reference state in which said wavelength band is attenuated relative to the measurement state. A controller is connected to each of the light source, the detector and the adaptable filter to change the adaptable filter between one of said measurement state and said reference state to the other at least once during a gas sensor operation period.

SYSTEMS AND METHODS FOR SKEWED BASIS SET FITTING

Systems and methods for skewed basis set fitting may include obtaining measured absorption data indicative of an amount of absorption of light by a sample gas at each of multiple frequencies, determining an absorption dependent cavity time constant indicative of a skew to the measured absorption data caused by light reflections within a cavity in which the sample gas is contained, obtaining reference absorption data including basis sets indicative of reference amounts of light absorbed by each of multiple gases at each of the multiple frequencies, skewing the reference absorption data based on the absorption dependent cavity time constant to generate skewed reference absorption data, and fitting the measured absorption data to the skewed reference absorption data to identify an amount of at least one constituent gas within the sample gas.

Optical device, gas sensor, methods of forming and operating the same

Various embodiments may relate to an optical device. The device may include an elongate substrate, an emitter portion at a distal end portion of the elongate substrate, the emitter portion configured to emit light, and an actuator portion at a proximal end portion of the elongate substrate opposite the distal end portion of the elongate substrate. The emitter portion may include a first electrode, a second electrode, and an active layer between the first electrode and the second electrode so that the light is emitted due to an increase in a temperature of the active layer upon application of a first potential difference between the first electrode and the second electrode. The active layer may be patterned to form a photonic crystal layer for enhancing directionality of the emitted light.