The invention relates to a method, to a device, and to a system for the automated determination of optical densities or of the change in optical densities of reaction mixtures in shaken reactors during shaking operation. Methods and devices currently used therefor are often unreliable, are susceptible to environmental and process factors, or require interruptions to the shaking operation that impair the process control. The problem addressed by the invention is that of specifying a method and a device for the automated determination of optical densities or of the change in optical densities of reaction mixtures in shaken reactors during shaking operation that operate reliably under various environmental and process conditions. This problem is solved by means of a new measurement method, wherein the reaction mixture distribution, which periodically fluctuates because of the shaking action, is used to record measurement points (20/21) of transmission/scattered-light measurements, which measurement points fluctuate periodically as a result of shaking. All measurement points (20/21) of a measurement operation are combined into a measurement series (34), from which the optical density and/or the change in the optical density, and other process parameters, can be determined with high reliability by means of suitable mathematical methods. The invention is suitable in particular for biotechnological, pharmaceutical, chemical, and biochemical screening and optimization and process-monitoring applications.

A method and instrument for determining optical density of a solution is disclosed. A flow cell 1 having at least three light paths (4a, 4b, 4c) is provided (100), wherein each light path has a respective predetermined path length, l. Absorbance readings are taken (400), A, of the solution at the at least three light paths (4a, 4b, 4c). For each pair of light paths, a slope, αc, is calculated (500) by dividing a difference in absorbance reading, ΔA, with a difference in path length, Δl. The calculated slopes, αc, are compared (600), and a) if the calculated slopes, αc, are the same, the slope is used for determining (700) optical density of the solution, or b) if he calculated slopes, αc, are not the same, the steepest slope of the calculated slopes is used for determining (701a) optical density of the solution, or the slope of the calculated slopes being in the range of an absorbance reading of 0.01 to 2 is used for determining (701b) optical density of the solution

Systems and methods for performing a contamination estimation of a downhole sample including at least a formation fluid and a filtrate are provided. A plurality of downhole signals are obtained from the downhole sample and one or more of the signals are conditioned. At least two of the conditioned signals or downhole signals are fused into a multivariate dataset. A principle component analysis (PCA) is performed on the fused multivariate dataset to determine optical and density properties of the formation fluid. Based on at least the PCA, optical and density properties of the filtrate are determined. From the optical and density properties of the formation fluid and of the filtrate, a multivariate calculation is performed to generate concentration profiles of the formation fluid and the filtrate.

A recording apparatus includes a channel through which liquid to be supplied to a recording head that ejects the liquid flows and a concentration measuring unit including a light emitting unit and a light receiving unit and configured to measure the concentration of the liquid, wherein the concentration measuring unit is disposed at a direction change portion at which the liquid flowing through the channel changes in direction.

Disclosed are systems and methods for performing a contamination estimation of a downhole sample comprising at least a formation fluid and/or a filtrate. A plurality of downhole signals are obtained from the downhole sample and one or more of the signals are conditioned. At least two of the conditioned signals or downhole signals are fused into a multivariate dataset. From optical and density properties of the formation fluid and/or of the filtrate, a multivariate calculation is performed to generate concentration profiles of the formation fluid and the filtrate.

A method and system for optical vortex transmissometry. The method uses optical orbital angular momentum (OAM) and optical vortices to discriminate coherent non-scattered light from incoherent scattered light. The system includes a laser which transmits a Gaussian laser beam through a medium. An OAM generating device is placed before a photodetector receiver. Coherent, non-scattered light passing through the OAM generating device forms an optical vortex, used to discriminate against the unwanted scattered signal that does not form a vortex. Alternatively, the system includes a transmitter, which generates one or more OAM modes, which are transmitted through a turbid medium. At the receiver, an OAM detection device analyzes the OAM mode spectrum of the received light. Coherent non-scattered light retains the OAM encoded at the transmitter, while scattered light does not. The attenuation of the channel is determined by comparison of the received OAM mode spectrum relative to the transmitted OAM mode spectrum.

A method for fast extracting an organic pollutant in a complex system is disclosed, which includes following steps. A surface-enhanced Raman scattering (SERS) spectrum of an organic pollutant is divided to obtain P wavelength sub-intervals with overlapping regions. The P wavelength sub-intervals are screened to obtain ω wavelength sub-intervals. The ω wavelength sub-intervals are screened to obtain a required wavelength sub-interval. The required wavelength sub-interval is screened to obtain a required wavelength subset. A method and a system for fast detecting an organic pollutant in a complex system are also disclosed.

A system consists of a detector and a detection card (9); the detector comprises a separation-detection turntable (4), a drive motor (3), a detection unit (5), a control and analysis unit (1), and a display unit (2); more than one detection card positions are arranged on the separation-detection turntable (4), and the separation-detection turntable (4) is driven by the drive motor (3) to rotate, so as to mix, separate and detect samples in the detection card; and the detection cards (9) are loaded on the detection card positions on the turntable, the detection card (9) is internally divided into more than two inner cavity pools, the divided inner cavity pools are respectively connected by narrow channels with a cross-sectional area less than 60% of a maximum cross-sectional area of each inner cavity pool, and all the inner cavity pools are unidirectionally connected in series.

Methods for identifying and providing therapeutic solutions for treating polymicrobial infections, such as but not limited to urinary tract infections, based on concordance between ABR genes and antibiotic susceptibility. The methods herein feature detection and identification of organisms of the polymicrobial infection, phenotypic pooled sensitivity tests for determining the susceptibility or resistance of the polymicrobial infection in the sample to an antibiotic or other therapeutic agent, and identification of resistance genes, e.g., genetic markers that may indicate resistance to a particular treatment. Together, the data can be applied against databases of antibiotic/therapeutic susceptibility or resistance for particular known polymicrobial infections in order to provide one or more therapeutic solutions for the polymicrobial infection.

A prism for measuring liquid concentration includes: an accommodating space for accommodating a liquid; an interface formed on a bottom surface of the accommodating space; a first light transmission surface and a second light transmission surface respectively formed on two side surfaces of the accommodating space; a third light transmission surface and a light emitting surface respectively formed relative to the interface. When a first incident light beam enters the prism, the first incident light beam is reflected to the light emitting surface by the interface, and exits the prism from the light emitting surface. When a second incident light beam enters the prism to the first light transmission surface, the second incident light beam exits the prism to the accommodating space from the second incident light beam, passes through the liquid and the second light to the prism, and exits the prism from the third light transmission surface.